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US 2014/0175686 A1Published application
Poorly Soluble Drug Containing Microspheres With Improved Bioavailability And Method Of Preparing The Same
AssigneeSamyang Biopharmaceuticals Corporation
InventorsKyung-Hee KIM, Hyun-Ki Lee, Jun-Seok Hwang, Su-Jong Hwang, Chaul-Min Pai
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Abstract
A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.
Claims10
A method for preparing a poorly soluble drug containing microsphere, comprising
- a) dissolving a water-soluble polymer carrier and a poorly soluble drug in water and an organic solvent to prepare a mixed solution;
- and
- b) spray drying the mixed solution,
- wherein the mixed solution does not include a surfactant, the weight ratio of the organic solvent and water is 0.5:1 to 5:1, and the poorly soluble drug is selected from the group consisting of acyclovir, candesartan, eprosartan, fenofibrate, atorvastatin, lovastatin, megestrol, simvastatin, sirolimus, tacrolimus and a combination thereof.
1 more element
Dependencies are inferred from the claim text.