Tritiated planar carbon forms
AssigneePerkinElmer Health Sciences, Inc.
InventorCrist N. Filer
Life of this patent
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Abstract
Tritiated planar carbon forms and their production are provided. Methods are provided for the stoichiometrically controlled labeling of planar carbon forms capitalizing on normal flaws of carboxylic acids ubiquitously present in commercial preparations of these planar carbon forms. Alternative methods include generation of a metallated intermediate whereby a metal is substituted for hydrogen on the carbon backbone of a planar carbon form. The metalized intermediate is then reacted with a tritium donor to covalently label the planar carbon form. The tritiated planar carbon forms produced are useful, for example, for determination of a biological property or environmental fate of planar carbon forms.
Claims32
A planar carbon form comprising one or more atoms of tritium covalently associated with said planar carbon form.
A method for producing a tritiated planar carbon form comprising:
- reacting a planar carbon form comprising one or more carboxylic acid groups on a surface of said planar carbon form, with a reducing agent capable of reducing a carboxylic acid so as to produce a tritiated planar carbon form with at least one atom of tritium associated with said surface.
A method for producing a tritiated planar carbon form comprising:
- forming a metallated planar carbon form by reacting a planar carbon form with a metal donor under conditions suitable for displacement of a hydrogen on a surface of said planar carbon form;
- and
- reacting said metallated planar carbon form with tritiated water to form a tritiated planar carbon form.
A method for producing a tritiated planar carbon form comprising:
- reacting an acyl functionalized planar carbon form having a surface with a reducing agent capable of reducing a ketone so as to produce a tritiated planar carbon form with at least one atom of tritium associated with said surface.
A method of detecting a planar carbon form in a sample comprising:
- supplementing a planar carbon form source with a tritiated planar carbon form to produce a labeled source;
- and
- detecting the presence or absence of a planar carbon form in a test sample derived from said labeled source by measuring the presence or absence of a beta particle emission from said sample.
Dependencies are inferred from the claim text.