Potentiometric device and method selective for pioglitazone
AssigneeUmm Al-Qura University
InventorAMR LOTFY SABER HEFNY
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Abstract
The potentiometric device and method selective for pioglitazone relates to the detection of pioglitazone in urine, in other liquid biological samples, and in pharmaceutical preparations for quality control testing and the like, and particularly to the use of a potentiometric sensor for potentiometric detection and measurement of the concentration of pioglitazone. The potentiometric sensor includes a plasticized polyvinyl chloride (PVC) matrix membrane having an ionophore impregnated or embedded therein. The ionophore is an iodobismuth anion in which the iodobismuth anion forms a complex with pioglitazone. The polymer membrane is plasticized with either ortho-nitrophenyl octyl ether (NPOE) or dioctyl phthalate (DOP).
Claims13
A potentiometric method selective for pioglitazone, comprising the steps of:
- at least partially filling a cell with a solution to be tested;
- at least partially immersing an ion selective electrode in the solution, the ion selective electrode having a plasticized polymer membrane doped with an ionophore, the ionophore being an ion-pair complex consisting of an iodobismuth-pioglitazone complex;
- measuring electrical potential between the ion selective electrode and a reference electrode;
- and
- comparing the measured potential with a calibration curve of the ion selective membrane to detect the presence of pioglitazone in the solution and determine the concentration thereof.
A polymer membrane selective for pioglitazone, comprising a membrane formed from a polymer doped with an ion-pair complex consisting of an iodobismuth-pioglitazone complex.
An ionophore selective for pioglitazone, consisting of a drug ion-pair complex, the ion-pair complex being an ion-pair complex consisting of an iodobismuth-pioglitazone complex.
Dependencies are inferred from the claim text.