Reduced risk tobacco products and methods of making same
AssigneeVector Tobacco, Inc.
InventorsAnthony P. Albino, Wendy Jin, Ellen Jorgensen
Life of this patent
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Abstract
Embodiments provided herein concern tobacco and tobacco products having a reduced amount of a harmful compound. More specifically, several embodiments concern approaches to modify the expression of a gene that is involved in the production of a harmful compound in tobacco, tobacco products made using these approaches and methods of determining whether the removal of said compounds using said approaches yields a tobacco and/or a tobacco product that has a reduced potential to contribute to a tobacco-related disease.
Claims2
A method of making a tobacco product with a reduced potential to contribute to a tobacco related disease comprising:
- a. providing a genetically modified tobacco configured to deliver a reduced amount of a compound that contributes to a tobacco related disease, as compared to a reference tobacco or a conventional tobacco;
- b. contacting a mammalian cell with smoke, or a smoke condensate obtained from said genetically modified tobacco;
- c. identifying a modulation of homeostasis of said cell, as compared to a control cell, which has been contacted with smoke, or a smoke condensate obtained from said reference tobacco or said conventional tobacco, wherein a decreased modulation of homeostasis in said cell compared to modulation of homeostasis in said control cell indicates a reduction in the potential to contribute to a tobacco related disease;
- and
- d. incorporating said identified genetically modified tobacco into a tobacco product.
A genetically modified tobacco having a reduced amount of nicotine as compared to conventional tobacco, further comprising a heterologous nucleic acid that encodes a gene that produces a composition selected from the group consisting of a medicinal compound, industrial oil, or dietary supplement, wherein said composition is substantially not present in conventional or wild-type tobacco.
Dependencies are inferred from the claim text.