Modulators of adp-dependent glucokinase (adpgk) and glycerol-3-phosphate dehydrogenase (gpd2) for therapy
AssigneeDeutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechtes
InventorsPeter Krammer, Marcin M. Kaminski, Karsten Gulow, Sven W. Sauer
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Abstract
Described are compounds capable of modulating (a) the biological activity of ADP-dependent glucokinase (ADPGK) and/or glycerol-3-phosphate dehydrogenase (GPD2) or (b) the expression of the gene encoding ADPGK or GPD2 for use in treating a disease (a) associated with aberrant cell proliferation, e.g., a neoplasm, or (b) of the immune system, e.g., an autoimmune disease.
Claims15
A compound capable of modulating (a) the biological activity of glycerol-3-phosphate dehydrogenase (GPD2) and/or ADP-dependent glucokinase (ADPGK) or (b) the expression of the gene encoding GPD2 or ADPGK for use in treating a disease (a) associated with aberrant cell proliferation or (b) of the immune system.
A method for identifying a compound capable of modulating the biological activity of GPD2 or ADPGK or the expression of the gene encoding GPD2 or ADPG, comprising the steps of:
- (a) incubating a candidate compound with a test system comprising GDP2 or ADPGK or the gene encoding ADPGK or GPD2;
- and
- (b) assaying a biological activity of GPD2 or ADPGK;
- wherein an increase or reduction of the biological activity of GPD2 or ADPGK is indicative of the presence of a candidate compound having the desired property.
Dependencies are inferred from the claim text.