Cyclitols and their derivatives and their therapeutic applications
AssigneesUniversite De Strasbourg, NormOxys, Inc.
InventorsJean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
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Abstract
The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
Claims16
-31. (canceled)
A composition comprising a pyrophosphate inositol which reduces hemoglobin's oxygen affinity, wherein:
- the pyrophosphate is an internal pyrophosphate;
- the inositol is cis-inositol, epi-inositol, allo-inositol, muco-inositol, neo-inositol, scyllo-inositol, (+) chiro-inositol, or (−) chiro-inositol, and wherein the pyrophosphate inositol is monopyrophosphate, bispyrophosphate, or trispyrophosphate;
- and
- the pyrophosphate inositol comprises a derivatized hydroxyl selected from alkoxy (—OR) or acyloxy (—OCOR),
- where R is selected from alkyl, aryl, acyl, aralkyl, alkenyl, alkynyl, heterocyclyl, polycyclyl, carbocycle, amino, acylamino, amido, alkylthio, sulfonate, alkoxyl, or sulfoxido, or a salt thereof.
A pharmaceutical composition, comprising a pyrophosphate inositol wherein:
- the pyrophosphate is an internal pyrophosphate;
- the inositol is cis-inositol, epi-inositol, allo-inositol, muco-inositol, neo-inositol, scyllo-inositol, (+) chiro-inositol, or (−) chiro-inositol, and wherein the pyrophosphate inositol is monopyrophosphate, bispyrophosphate, or trispyrophosphate;
- and
- the pyrophosphate inositol comprises a derivatized hydroxyl selected from alkoxy (—OR) or acyloxy (—OCOR),
- where R is selected from alkyl, aryl, acyl, aralkyl, alkenyl, alkynyl, heterocyclyl, carbocycle, amino, acylamino, amido, alkylthio, sulfonate, alkoxyl, or a salt selected from an alkali metal cation, an alkaline metal cation, ammonium, or an organic cation.
Dependencies are inferred from the claim text.