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US 2014/0163101 A1Published application
Caprylate viral deactivation
AssigneeGrifols, S.A.
InventorsWytold Lebing, Doug Burns, Nathan Roth, Joann Hotta
Life of this patent
Estimating the term…
Abstract
Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.
Claims26
A method of preparing albumin from a solution comprising albumin comprising:
- adjusting the protein concentration of the solution to less than about 5%;
- adjusting pH of the solution to about pH 5 or less;
- adding caprylic acid (octanoic acid) or sodium caprylate;
- raising the solution temperature greater than about 20° C.;
- and
- incubating the solution.
3 more elements
A method of preparing albumin from a solution comprising albumin:
- adjusting the protein concentration of the solution to less than about 5%;
- adjusting pH of the solution to about pH 5 or less;
- adding caprylic acid (octanoic acid) or sodium caprylate to a concentration of about 20 mM;
- raising the solution temperature to about 27-30° C.;
- and
- incubating the solution for at least about 30 min to about 120 min.
3 more elements
A method of inactivating viruses in a solution comprising albumin, the method comprising:
- adjusting the protein concentration of solution to about 5% protein;
- adjusting pH of the solution to less than about 5;
- adding caprylic acid (octanoic acid) or sodium caprylate;
- raising the solution temperature greater than about 20° C.;
- and
- incubating the solution.
3 more elements
A method of inactivating viruses in a solution comprising albumin, the method comprising:
- adjusting the protein concentration of solution to about 5% protein;
- adjusting pH of the solution to less than about 5;
- adding caprylic acid (octanoic acid) or sodium caprylate to a concentration of about 20 mM;
- raising the solution temperature to about 27-30° C.;
- and
- incubating the solution for at least 90 min.
3 more elements
Dependencies are inferred from the claim text.