# US 2014/0156247 A1 · Computer-Implemented Method For Simulating, In A Three-Dimensional Scene, The Evolution Of Biological Data > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0156247 A1 - Document ID: US20140156247A1 - Status: Published application - Kind: A1 - Application number: 14/094,629 - Filed: 2013-12-02 - Published: 2014-06-05 - Earliest claimed: 2012-12-03 - Assignees: Dassault Systemes - Applicants: Dassault Systemes - Inventors: Sylvain Pradalier; Gwenael Kervizic - Web page: https://patentgrep.com/patent/US20140156247A1 ## CPC - G16H 50/50: for simulation or modelling of medical disorders - G16B 45/00: ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks - G16B 5/00: ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA - G16B: BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY ## Abstract A computer-implemented method for simulating, in a three-dimensional scene, the evolution of biological data comprising the steps of: displaying an initial biological interaction network (BIN) of biological entities; and determining biological data for said interaction network (BIN); characterized in that the method further comprises the step of: displaying, in a three-dimensional scene, a biological data of each entity in a first layout (2, 3, 4, 5), a first layout comprising several levels, a level corresponding to the value of the biological data at a time instant (t). ## Claims ### Claim 1 A computer-implemented method for simulating, in a three-dimensional scene, the evolution of biological data comprising the steps of: displaying an initial biological interaction network (BIN) of biological entities; and determining biological data for said interaction network (BIN); characterized in that the method further comprises the step of: displaying, in a three-dimensional scene, a biological data of each entity in a first layout (2, 3, 4, 5), a first layout comprising several levels, a level corresponding to the value of the biological data at a time instant (t). ### Claim 2 (depends on 1) Method according to claim 1, wherein the layout is displayed as a column (2, 3, 4, 5). ### Claim 3 (depends on 1) Method according to claim 1, wherein the levels of a layout are displayed in a continuous manner. ### Claim 4 (depends on 1) Method according to claim 1, wherein the levels of a layout (2, 3, 4, 5) are displayed in a discretized manner. ### Claim 5 (depends on 1) Method according to claim 1, further comprising, the steps of: creating a virtual node of the biological interaction network (BIN) corresponding to an information representative of a biological data of several biological entities of the initial biological interaction network (BIN); and displaying, in the three-dimensional scene, a layout (9, 10) comprising several levels, a level corresponding to the value of said information at a time instant. ### Claim 6 (depends on 5) Method according to claim 5, wherein said information is a function of a biological data of the several biological entities of the initial biological interaction network (BIN). ### Claim 7 (depends on 6) Method according to claim 6, wherein said function comprises a sum and/or a mean of biological entity or entities of the initial biological interaction network (BIN). ### Claim 8 (depends on 6) Method according to claim 6, wherein said information is representative of the toxicity of the biological entities of the initial biological interaction network (BIN). ### Claim 9 (depends on 1) Method according to claim 1, further comprising, the step of displaying an adjusting layout (6) comprising means to scroll (7) the displayed time range of the all layouts (2, 3, 4, 5) and/or comprising means to highlight (8) a same time instant of each layout. ### Claim 10 (depends on 1) Method according to claim 1, further comprising a step of displaying, in the three-dimensional scene, a biological data of each entity in a second layout (11, 12, 13, 14), a second layout (11, 12, 13, 14) comprising several levels, a level corresponding to the value of the biological data at a time instant, one of the first layout (2, 3, 4, 5) and the second layout (11, 12, 13, 14) represents simulation values and the other one represents experiment values. ### Claim 11 (depends on 11) Method according to claim 11, further comprising a step of switching the display of a type of layouts, among first and second layouts, between a two-dimensional aspect and a three-dimensional aspect. ### Claim 12 (depends on 11) Method according to claim 11, wherein a type of layout has a cylindrical aspect in a three-dimensional displaying, and a concentric rings aspect in a two-dimensional displaying. ### Claim 13 (depends on 1) Method according to claim 1, wherein the number of displayed levels is configurable. ### Claim 14 A computer-readable medium comprising: computer-executable instructions embodied on the computer-readable medium that cause a computer system to perform a method for simulating, in a three-dimensional scene, the evolution of biological data by: displaying an initial biological interaction network (BIN) of biological entities; and determining biological data for said interaction network (BIN); characterized in that the method further comprises the step of: displaying, in a three-dimensional scene, a biological data of each entity in a first layout (2, 3, 4, 5), a first layout comprising several levels, a level corresponding to the value of the biological data at a time instant (t). ### Claim 15 A computer program product, comprising: a computer readable medium, for simulating the evolution of biological data in a three-dimensional scene of a computer-aided (CAD) system, the computer readable medium comprising code means for causing the CAD system to take the steps of: displaying an initial biological interaction network (BIN) of biological entities; and determining biological data for said interaction network (BIN); characterized in that the method further comprises the step of: displaying, in a three-dimensional scene, a biological data of each entity in a first layout (2, 3, 4, 5), a first layout comprising several levels, a level corresponding to the value of the biological data at a time instant (t). ### Claim 16 An apparatus for simulating the evolution of biological data in a three-dimensional scene of a computer-aided system comprising: computer means for: displaying an initial biological interaction network (BIN) of biological entities; and determining biological data for said interaction network (BIN); characterized in that the method further comprises the step of: displaying, in a three-dimensional scene, a biological data of each entity in a first layout (2, 3, 4, 5), a first layout comprising several levels, a level corresponding to the value of the biological data at a time instant (t).