# US 2014/0155956 A1 · Neuromodulation to treat menopause-related conditions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155956 A1 - Document ID: US20140155956A1 - Status: Published application - Kind: A1 - Application number: 14/093,094 - Filed: 2013-11-29 - Published: 2014-06-05 - Earliest claimed: 2012-11-28 - Assignees: Autonomic Technologies, Inc. - Applicants: Autonomic Technologies, Inc. - Inventors: Benjamin D. Pless; Shannon Schuetz - Web page: https://patentgrep.com/patent/US20140155956A1 ## CPC - A61N 1/36171: {Frequency} - A61N 1/36175: {Pulse width or duty cycle} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract One aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include inserting a therapy delivery device into a vessel of the subject. Next, the therapy delivery device can be advanced to a point substantially adjacent a target site of the sympathetic nervous system (SNS) that is associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition. ## Claims ### Claim 1 A method for treating a menopause-related condition in a subject, the method comprising the steps of: inserting a therapy delivery device into a vessel of the subject; advancing the therapy delivery device to a point substantially adjacent a target site of the sympathetic nervous system (SNS) that is associated with the menopause-related condition; and activating the therapy delivery device to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition. ### Claim 2 (depends on 1) The method of claim 1, wherein the target site of the SNS is a cervical ganglion. ### Claim 3 (depends on 1) The method of claim 1, wherein delivery of the therapy signal to the target site of the SNS substantially blocks sympathetic activity at the target site. ### Claim 4 (depends on 1) The method of claim 1, further comprising the step of programming the therapy delivery device so that the therapy signal is automatically delivered to the target site of the SNS at a pre-determined frequency and intensity. ### Claim 5 (depends on 1) The method of claim 1, wherein the subject causes selective delivery of the therapy signal to the target site of the SNS by inductively coupling the therapy delivery device to a power source. ### Claim 6 (depends on 1) The method of claim 1, wherein the menopause-related condition is hot flashes. ### Claim 7 (depends on 1) The method of claim 1, wherein the therapy delivery device is positioned within one of an intercostal vein, an intercostal artery, or a subclavian artery. ### Claim 8 A method for treating a menopause-related condition in a subject, the method comprising the steps of: placing a therapy delivery device, without penetrating the skin of the subject, into electrical communication with a target site of the SNS that is associated with the menopause-related condition; and activating the therapy delivery device to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition. ### Claim 9 (depends on 8) The method of claim 8, further comprising the step of placing the therapy delivery device on the skin of the subject. ### Claim 10 (depends on 8) The method of claim 8, wherein the target site of the SNS is a cervical ganglion. ### Claim 11 (depends on 8) The method of claim 8, wherein delivery of the therapy signal to the target site of the SNS substantially blocks sympathetic activity at the target site. ### Claim 12 (depends on 8) The method of claim 8, further comprising the step of programming the therapy delivery device so that the therapy signal is automatically delivered to the target site of the SNS at a pre-determined frequency and intensity. ### Claim 13 (depends on 9) The method of claim 9, wherein the menopause-related condition is hot flashes. ### Claim 14 A method for treating a menopause-related condition in a subject, the method comprising the steps of: implanting a therapy delivery device in the subject so that the therapy delivery device is in electrical contact with a target site of the SNS associated with the menopause-related condition; and activating the therapy delivery device to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition. ### Claim 15 (depends on 14) The method of claim 14, wherein the target site of the SNS is a cervical ganglion. ### Claim 16 (depends on 14) The method of claim 14, wherein delivery of the therapy signal to the target site of the SNS substantially blocks sympathetic activity at the target site. ### Claim 17 (depends on 14) The method of claim 14, further comprising the step of programming the therapy delivery device so that the therapy signal is automatically delivered to the target site of the SNS at a pre-determined frequency and intensity. ### Claim 18 (depends on 14) The method of claim 14, wherein the subject causes selective delivery of the therapy signal to the target site of the SNS by inductively coupling the therapy delivery device to a power source. ### Claim 19 (depends on 14) The method of claim 14, wherein the menopause-related condition is hot flashes.