# US 2014/0155952 A1 · Method of treating depression, mood disorders and anxiety disorders using neuromodulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155952 A1 - Document ID: US20140155952A1 - Status: Published application - Kind: A1 - Application number: 13/913,189 - Filed: 2013-06-07 - Published: 2014-06-05 - Earliest claimed: 2003-06-19 - Assignees: Advanced Neuromodulation Systems, Inc. - Applicants: Advanced Neuromodulation Systems, Inc. - Inventors: Andres M. Lozano; Helen S. Mayberg - Web page: https://patentgrep.com/patent/US20140155952A1 ## CPC - A61M 5/14276: {specially adapted for implantation} - A61B 5/4848: {Monitoring or testing the effects of treatment, e.g. of medication} - A61N 1/0534: {Electrodes for deep brain stimulation} - A61N 1/36096: {Mood disorders, e.g. depression, anxiety or panic disorder} - A61N 1/36185: {Selection of the electrode configuration} - A61P 25/00: Drugs for disorders of the nervous system - A61P 25/24: Antidepressants - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety. ## Claims ### Claim 1 A method of treating a mood and/or anxiety disorder comprising the steps of: obtaining imaging data of a brain of a patient; identifying a target location, using the imaging data, within or immediately adjacent to a Brodmann area 24/25 site of an anterior cingulate of the patient; surgically implanting a stimulation lead according to the target location within the patient such that at least one electrode is within or in contact with a Brodmann area 24/25 site of the anterior cingulate of the patient; operating a pulse generator to generate electrical pulses to stimulate neuronal tissue using the at least one electrode; and monitoring changes in the mood and/or anxiety disorder of the patient after performing the operating. ### Claim 2 (depends on 1) The method of claim 1 further comprising: performing functional magnetic resonance imaging to determine whether the operating results in modulation of neuronal activity in Brodmann area 25. ### Claim 3 (depends on 1) The method of claim 1 further comprising: performing functional magnetic resonance imaging to determine whether the operating results in modulation of neuronal activity in Brodmann area 24. ### Claim 4 (depends on 1) The method of claim 1, wherein the mood and/or anxiety disorder is selected from the group consisting of major depressive disorder, bipolar disorder, and dysthymic disorder. ### Claim 5 (depends on 1) The method of claim 1, wherein the mood and/or anxiety disorder is major depressive disorder. ### Claim 6 (depends on 1) The method of claim 1, wherein the mood and/or anxiety disorder is selected from the group consisting of panic disorder, posttraumatic stress disorder, obsessive-compulsive disorder and phobic disorder. ### Claim 7 (depends on 1) The method of claim 1 further comprising: applying stimulation using a plurality of electrodes of the stimulation lead during a trial period; and selecting one of the electrodes for chronic stimulation according to detected neuronal activity from functional magnetic resonance imaging. ### Claim 8 (depends on 7) The method of claim 7 wherein the detected neuronal activity is neuronal activity within Brodmann area 25. ### Claim 9 (depends on 1) The method of claim 1 wherein the identifying comprises: identifying the target location within 2 mm to 14 mm from a midline of the patient's brain. ### Claim 10 (depends on 1) The method of claim 1 wherein the identifying comprises: identifying the target location within 20 mm to 40 mm from a mid-commissural point of the patient's brain. ### Claim 11 (depends on 1) The method of claim 1 wherein the identifying comprises: identifying the target location within 0 mm to 10 mm below an intra-commissural line of the patient's brain.