# US 2014/0155904 A1 · Biomaterials Containing Calcium Phosphate > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155904 A1 - Document ID: US20140155904A1 - Status: Published application - Kind: A1 - Application number: 13/923,577 - Filed: 2013-06-21 - Published: 2014-06-05 - Earliest claimed: 2008-06-23 - Assignees: Centre Hospitalier Universitaire De Nice; Center National de la Recherche Scientifique - Applicants: Centre Hospitalier Universitaire de Nice; Center National de la Recherche Scientifique - Inventors: Thierry Balaguer; Nathalie Rochet; Georges Carle - Web page: https://patentgrep.com/patent/US20140155904A1 ## CPC - A61K 33/42: Phosphorus; Compounds thereof - A61B 17/8805: {for introducing fluid filler into bone or extracting it (A61B17/7097, A61B17/8833 take precedence)} - A61K 33/14: Alkali metal chlorides; Alkaline earth metal chlorides - A61L 27/12: Phosphorus-containing materials, e.g. apatite - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L 2300/418: Agents promoting blood coagulation, blood-clotting agents, embolising agents - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The invention relates to a biomaterial containing calcium phosphate, in particular hydroxyapatite or a material containing hydroxyapatite, such as biphasic calcium phosphates and calcium phosphate cements, and to the use thereof for the production of an implant or for fitting a prosthesis for the purpose of bone tissue regeneration. ## Claims ### Claim 1 A biomaterial, comprising a calcium phosphate-comprising support, and at least one calcium-comprising coagulating agent in dry and/or solid powder form, wherein the support is selected from the group consisting of hydroxyapatite (HA) and a biphasic calcium phosphate (BCP), wherein the coagulating agent is present in a proportion ranging from 2.5 to 60 μmol of calcium per gram of HA or of BCP. ### Claim 2 (depends on 1) The biomaterial of claim 1, wherein the coagulating agent is present in a proportion ranging from 5 to 40 μmol of calcium per gram of HA or of BCP. ### Claim 3 (depends on 1) The biomaterial of claim 1, wherein the coagulating agent is CaCl2. ### Claim 4 (depends on 1) The biomaterial of claim 1, wherein the support is in monolith form. ### Claim 5 (depends on 1) The biomaterial of claim 1, wherein the support is in granule form. ### Claim 6 (depends on 1) The biomaterial of claim 1, further comprising at least one additive selected from the group consisting of a polymer, a ceramic particle, a pharmaceutical molecule, a natural growth factor, a synthetic growth factor, a natural biomarker, a synthetic biomarker, a natural contrast agent, a synthetic contrast agent, a natural tissue preparation, a synthetic tissue preparation, a natural cell preparation, and a synthetic cell preparation. ### Claim 7 (depends on 1) A method for filling a bone defect, the method comprising implanting the biomaterial of claim 1 into bone tissue. ### Claim 8 (depends on 7) A method according to claim 7, further comprising a step of impregnating the biomaterial in situ with an aqueous solution. ### Claim 9 (depends on 7) A method according to claim 7, wherein the biomaterial is impregnated with an aqueous solution just before its implantation. ### Claim 10 (depends on 8) The method according to claim 8, wherein the aqueous solution is physiological saline. ### Claim 11 (depends on 7) A method according to claim 7, further comprising a step wherein the biomaterial is left to be impregnated with the blood from the surrounding tissues. ### Claim 12 (depends on 1) A combination, comprising the biomaterial of claim 1 and an osteosynthesis. ### Claim 13 A kit comprising a combination of a calcium phosphate-comprising support with a calcium-derived coagulating agent in dry and/or powder form, wherein the support is selected from the group consisting of hydroxyapatite (HA) and a biphasic calcium phosphate (BCP) support, the calcium-derived coagulating agent being present in a proportion ranging from 2.5 to 60 μmol of calcium per gram of HA or of BCP. ### Claim 14 (depends on 13) The kit as claimed in claim 13, wherein the calcium-derived coagulating agent is present in a proportion ranging from 5 to 40 μmol of calcium per gram of HA or of BCP. ### Claim 15 (depends on 14) The kit as claimed in claim 14, wherein the amount of coagulating agent is calculated so as to compensate for the anticoagulant effect of the calcium phosphate and to promote blood coagulation. ### Claim 16 (depends on 14) The kit of claim 14, wherein the coagulating agent is CaCl2. ### Claim 17 (depends on 14) The kit of claim 14, which comprises: (a) a sterile device comprising a sterile internal cavity in which the support is placed; and (b) a sterile reservoir comprising the coagulating agent. ### Claim 18 (depends on 14) The kit of claim 14, wherein the device (a) comprises an element which allows the biomaterial to be applied in a region where a bone defect has been noted. ### Claim 19 (depends on 14) The kit of claim 14, wherein the device (a) consists of a syringe. ### Claim 20 (depends on 1) A method of producing bone tissue, comprising combining, in vitro or ex vivo, the biomaterial of claim 1, with bone cells. ### Claim 21 (depends on 1) A method of producing bone implant, comprising combining, in vitro or ex vivo, the biomaterial of claim 1 with bone cells or a prosthesis mould.