# US 2014/0155828 A1 · Prefilled syringe jet injector > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155828 A1 - Document ID: US20140155828A1 - Status: Published application - Kind: A1 - Application number: 14/173,659 - Filed: 2014-02-05 - Published: 2014-06-05 - Earliest claimed: 2005-01-24 - Assignees: Antares Pharma, Inc. - Applicants: Antares Pharma, Inc. - Inventors: Paul R. Lesch, JR. - Web page: https://patentgrep.com/patent/US20140155828A1 ## CPC - A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)} - A61M 5/178: Syringes - A61M 5/28: Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle - A61M 5/30: Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules - A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)} - A61M 5/46: having means for controlling depth of insertion - A61M 5/484: {Regulating injection pressure} - A61M 5/206: {with automatic needle insertion} - A61M 2005/2013: {triggering of discharging means by contact of injector with patient body} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site. ## Claims ### Claim at position 1 1-22. (canceled) ### Claim 23 A jet injector, comprising: a prefilled syringe comprising: a container portion defining a fluid chamber containing a medicament, an injection-assisting needle disposed at a distal end of the fluid chamber, the injection-assisting needle having an injection tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the fluid chamber for injecting the medicament from the fluid chamber into an injection site, wherein the injection-assisting needle is adhered to the container portion, a syringe body that includes a flange and a wall and hub of unitary construction, and a plunger movable within the fluid chamber, a housing that houses the prefilled syringe and is configured for allowing insertion of the injection-assisting needle at the injection location to an insertion point that is at a penetration depth below a surface at the insertion location; a syringe support supportively mounting the prefilled syringe to the housing; a syringe cushion associated with the syringe support and prefilled syringe and made of an elastomeric material to compensate for shape irregularities of the pre-filled syringe, and an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains below 500 p.s.i. during the injection of the medicament to jet inject the medicament from the fluid chamber through the injection-assisting needle to the injection site. ### Claim 24 (depends on 23) The jet injector of claim 23, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains up to about 350 p.s.i. during the injection of the medicament. ### Claim 25 (depends on 24) The jet injector of claim 24, wherein the energy source is configured to produce the injecting pressure that remains at least at about 90 p.s.i. during the injection of the medicament. ### Claim 26 (depends on 23) The jet injector of claim 23, wherein the penetration depth is between about 0.5 mm and 5 mm below the surface at the insertion location. ### Claim 27 (depends on 23) The jet injector of claim 23, wherein the housing is configured for allowing insertion of the needle to subcutaneous depth. ### Claim 28 (depends on 23) The jet injector of claim 23, wherein the energy source comprises a spring. ### Claim 29 (depends on 28) The jet injector of claim 28, further comprising a ram that is biased by the spring against the plunger to produce the injection pressure, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe when the jet injector is fired, such that the spring surrounds the prefilled syringe. ### Claim 30 (depends on 23) The jet injector of claim 23, wherein: the prefilled syringe has a distal portion in which the injection-assisting needle is located, and a proximal portion opposite the distal portion; and the syringe support axially supports the proximal portion of the pre-filled syringe during the jet injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axially direction. ### Claim 31 (depends on 23) The jet injector of claim 23, wherein the fluid chamber contains about between 0.02 mL and 4 mL of the medicament. ### Claim 32 (depends on 23) The jet injector of claim 23, wherein the housing comprises a retractable guard that is movable between: a protecting position in which the injection-assisting needle is disposed within the guard; and an injecting position in which the tip of the injection-assisting needle is exposed for insertion to the insertion point. ### Claim 33 (depends on 32) The jet injector of claim 32, further comprising a trigger mechanism operable associated with the energy source for activating the energy source to jet inject the medicament, wherein the trigger mechanism is configured for activating the energy source after the retractable guard is retracted from the protecting position. ### Claim 34 (depends on 33) The jet injector of claim 33, wherein the retractable guard is operable associated with the trigger mechanism to cause the trigger mechanism to activate the energy source when the retractable guard is retracted to the injecting position. ### Claim 35 (depends on 33) The jet injector of claim 33, wherein the penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament. ### Claim 36 A jet injector, comprising: a prefilled syringe comprising: a container portion defining a fluid chamber containing a medicament, an injection-assisting needle disposed at a distal end of the fluid chamber, an injecting tip configured for piercing an insertion location and defining a fluid pathway in fluid communication with the fluid chamber for injecting the medicament from the fluid chamber into an injection site, wherein the injection-assisting needle is adhered to the container portion, a syringe body that includes a flange and a wall and hub of unitary construction, and a plunger movable within the fluid chamber, a housing that houses the prefilled syringe and is configured for allowing insertion of the injection-assisting needle at the injection location to an insertion point that is at a penetration depth of up to 5 mm below a surface at the insertion location; a syringe support supportively mounting the prefilled syringe to the housing; a syringe cushion associated with the syringe support and prefilled syringe and made of an elastomeric material to compensate for shape irregularities of the pre-filled syringe, and an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains below 500 p.s.i. during injection of the medicament to jet inject the medicament from the fluid chamber through the injection-assisting needle to an injection site remote from the injecting tip. ### Claim 37 (depends on 36) The jet injector of claim 36, wherein the penetration depth is between about 1 mm and 4 mm. ### Claim 38 (depends on 36) The jet injector of claim 36, wherein the penetration depth is up to about 3 mm below the surface of at the insertion location. ### Claim 39 (depends on 36) The jet injector of claim 36, wherein the injecting pressure and penetration depth are sufficient such that the injection site is subcutaneous. ### Claim 40 (depends on 36) The jet injector of claim 36, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains above about 90 p.s.i. during the injection of the medicament. ### Claim 41 (depends on 23) The jet injector of claim 23, wherein the prefilled syringe is associated with the housing in a fixed position before and during activation of the energy source for firing of the jet injector. ### Claim 42 (depends on 23) The jet injector of claim 23, wherein the syringe cushion comprises a resilient sleeve portion configured to provide shock absorption during firing of the jet injector. ### Claim 43 (depends on 23) The jet injector of claim 23, wherein the syringe cushion supports the flange. ### Claim 44 A jet injector, comprising: a prefilled syringe comprising: a container portion defining a fluid chamber containing a medicament, an injection-assisting needle disposed at a distal end of the fluid chamber, the injection-assisting needle having an injection tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the fluid chamber for injecting the medicament from the chamber into an injection site, wherein the injection-assisting needle is adhered to the container portion, a syringe body that includes a flange and a wall and hub of unitary construction and a plunger movable within the fluid chamber; a housing that houses the prefilled syringe and is configured for allowing insertion of the injection-assisting needle at the injection location to an insertion point that is at a penetration depth below a surface at the insertion location; an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains up to 350 p.s.i. during injection of the medicament; and an elastomeric cushion configured to compensate for shape irregularities of the prefilled syringe and absorb energy when the energy source is activated; wherein the prefilled syringe is associated with the housing in a fixed position before and during activation of the energy source for firing of the jet injector.