# US 2014/0155760 A1 · Remote and local transfer of information in noninvasive hydration measurements > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155760 A1 - Document ID: US20140155760A1 - Status: Published application - Kind: A1 - Application number: 14/176,051 - Filed: 2014-02-08 - Published: 2014-06-05 - Earliest claimed: 2012-02-15 - Inventors: Trent Daniel Ridder; Benjamin Ver Steeg; Bentley Laaksonen - Web page: https://patentgrep.com/patent/US20140155760A1 ## CPC - A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)} - A61B 5/1171: based on the shapes or appearances of their bodies or parts thereof - A61B 5/443: {Evaluating skin constituents, e.g. elastin, melanin, water} - A61B 5/4869: {Determining body composition} - A61B 5/4875: {Hydration status, fluid retention of the body} - A61B 5/6835: {Supports or holders, e.g., articulated arms} - A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet} - A61B 5/117: Identification of persons (methods or arrangements for recognising patterns, e.g. fingerprints, G06F18/00, G06V40/00; identification of persons by analysing their voice or speech G10L17/00) - A61B 5/6824: {Arm or wrist} - A61B 5/70: {Means for positioning the patient in relation to the detecting, measuring or recording means} - A61B 5/7203: {for noise prevention, reduction or removal} - A61B 5/7257: {using Fourier transforms} - A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors - A61B 2562/0233: Special features of optical sensors or probes classified in A61B5/00 - A61B 2562/0242: for varying or adjusting the optical path length in the tissue - A61B 2562/04: Arrangements of multiple sensors of the same type - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract An apparatus and method for non-invasive determination of hydration, hydration state, total body water, or water concentration by quantitative spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectroscopy, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance, and calibration transfer. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The system can include a plurality of measurement devices, configured to communicate with each other and with a remote receiver or centralized server. The invention contemplates novel ways to arrange various subsystems and to provide operability and communication among them. ## Claims ### Claim 1 A system to determine a hydration state of a subject, comprising: (a) a first measurement device, configured to determine a spectroscopic signal representative of the response of the subject's tissue to incident light; (b) a first communications subsystem mounted with the measurement device, configured to communicate information between the first measurement device and a first centralized server; (c) an analysis system configured to determine intravascular hydration, extravascular hydration, or both, from a spectroscopic signal determined by the first measurement device. ### Claim 2 (depends on 1) A system as in claim 1, wherein the analysis system comprises a data processing system, and wherein the first communications subsystem is configured to communicate spectroscopic information from the first measurement device to the analysis system. ### Claim 3 (depends on 1) A system as in claim 1, wherein the analysis system is mounted with the first measurement device, and wherein the first communications system is configured to communicate information concerning hydration state to the first centralized server. ### Claim 4 (depends on 1) A system as in claim 1, further comprising a second measurement device configured to determine a spectroscopic signal representative of the response of a subject's tissue to incident light; and a second communications system mounted with the second measurement device, configured to communicate information between the second measurement device and the first centralized server. ### Claim 5 (depends on 4) A system as in claim 4, wherein the first centralized server is mounted with the first measurement device. ### Claim 6 (depends on 1) A system as in claim 1, further comprising first and second centralized servers configured to communicate information with each other, and further comprising a second measurement device configured to determine a spectroscopic signal representative of the response of a subject's tissue to incident light; and a second communications system mounted with the second measurement device, configured to communicate information between the second measurement device and the second centralized server. ### Claim 7 (depends on 6) A system as in claim 6, wherein the first centralized server is configured to communicate information regarding hydration state with one or more other data processing systems. ### Claim 8 (depends on 7) A system as in claim 7, wherein the first centralized server is configured to communicate spectroscopic information with one or more other data processing systems. ### Claim 9 (depends on 7) A system as in claim 7, wherein the first centralized server is configured to communicate hydration state determinations of the analysis system with one or more other data processing systems. ### Claim 10 (depends on 7) A system as in claim 7, wherein the first centralized server is configured to communicate information regarding aggregation of hydration results across multiple hydration state determinations with one or more other data processing systems. ### Claim 11 (depends on 1) A system as in claim 1, wherein the first communications subsystem is configured to encrypt information before transmitting the information. ### Claim 12 (depends on 1) A system as in claim 1, wherein the first measurement device communicates with the first centralized server at predetermined intervals. ### Claim 13 (depends on 1) A system as in claim 1, wherein the first measurement device communicates with the first centralized server upon the occurrence of predetermined events. ### Claim 14 (depends on 1) A system as in claim 1, wherein the first measurement device communicates hydration results to the first centralized server. ### Claim 15 (depends on 1) A system as in claim 1, wherein the first measurement device communicates information concerning operating history of the first measurement device. ### Claim 16 (depends on 4) A system as in claim 4, wherein the first centralized server further comprises an analytics system configured to determine analytical information from aggregations of information collected at multiple measurement devices. ### Claim 17 (depends on 1) A system as in claim 1, wherein the first centralized server communicates directions concerning actions to be taken responsive to hydration information determined by the analysis system. ### Claim 18 (depends on 1) A system as in claim 1, wherein the first measurement device is configured to determine a spectroscopic signal at a plurality of times spanning at least one heartbeat of the subject, and wherein the analysis system is configured to determine intravascular hydration from one or more components of the spectroscopic signal that varies with the heartbeat of the subject. ### Claim 19 (depends on 13) A system as in claim 13, wherein the analysis system is configured to determine a frequency corresponding to the heart rate of the subject, and to determine intravascular hydration from components of the spectroscopic signal that vary at the determined frequency. ### Claim 20 (depends on 1) A system as in claim 1, wherein the analysis system is configured to determine intravascular hydration from the spectroscopic signal according to a first method, and to determine extravascular hydration from the spectroscopic signal according to a second method, wherein the first method is distinct from the second method. ### Claim 21 (depends on 1) A system as in claim 1, comprising a first centralized server, wherein the first centralized server comprises at least one of a mobile phone, a tablet computer, a laptop computer, a desktop computer. ### Claim 22 (depends on 1) A system as in claim 1, comprising a first centralized server, wherein the first centralized server is configured to communicate with at least one of a mobile phone, a tablet computer, a laptop computer, a desktop computer.