# US 2014/0155633 A1 · Composition for Stabilizing Ascorbic Acid Derivatives and the Application Thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155633 A1 - Document ID: US20140155633A1 - Status: Published application - Kind: A1 - Application number: 13/689,971 - Filed: 2012-11-30 - Published: 2014-06-05 - Earliest claimed: 2012-11-30 - Assignees: Corum Inc. - Applicants: Corum Inc. - Inventors: Lin-Chao Chen; Yu-Ling Shiu; Chia-Pei Lee; Chao-Yang Lee - Web page: https://patentgrep.com/patent/US20140155633A1 ## CPC - A61K 8/676: {Ascorbic acid, i.e. vitamin C} - A61K 8/55: Phosphorus compounds - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof - A61K 47/12: Carboxylic acids; Salts or anhydrides thereof - A61Q 19/00: Preparations for care of the skin - A61K 2800/10: General cosmetic use - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract This invention discloses a composition for stabilizing ascorbic acid derivative and the application thereof. The mentioned composition comprises ascorbic acid derivative, buffer, phosphonic acid derivative and at least one alcohol. The yellowish and degradation of ascorbic acid derivative can be efficiently decreased by the mentioned composition. Moreover, the mentioned composition can be used in topical composition, such as toner, serum, lotion, cream. ## Claims ### Claim 1 A clear composition for stabilizing ascorbic acid derivative comprising: an ascorbic acid derivative, wherein a general formula of the ascorbic acid derivative is as the following, wherein R is selected from one of the group consisting of the following: C1-C20 alkyl group, C3-C20 cycloalkyl group, C1-C20 heterocycloalkyl group, C1-C20 alkoxy group, C2-C20 acyl group, C6-C20 aryl group, C1-C20 heterocyclic aromatic group, C3-C20 cycloalkenyl group; a buffer, wherein the buffer is employed to adjust pH value of the composition between 3.5 and 5.5; and a stabilizing agent consisted of phosphonic acid derivative and alcohol, wherein said alcohol is selected from one or the combination of the group consisting of the following: ethanol, propylene glycol, 1,3-propanediol, dipropylene glycol, butylene glycol, ethoxydiglycol, and polypolyethylene glycol (PEG). ### Claim 2 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein said buffer is selected from one of the group consisting of the following: citric acid/sodium citrate, citric acid/sodium phosphate, and acetic acid/sodium acetate. ### Claim 3 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein said phosphonic acid derivative is selected from one of the group consisting of the following: N,N,N′,N′-ethylenediaminetetrakis(methylenephosphonic acid) hydrate (EDTMP), hexaMethylenediaminetetra (methylenephosphonic Acid) (HMDTMPA), Diethylene Triamine Penta (Methylene Phosphonic Acid) (DTPMPA) and the salts thereof. ### Claim 4 (canceled) ### Claim 5 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the quantity of the ascorbic acid derivative is from 0.01 to 10% of the total weight of the composition. ### Claim 6 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the quantity of the ascorbic acid derivative is from 0.1 to 4.0% of the total weight of the composition. ### Claim 7 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the quantity of the phosphonic acid derivative is from 0.01 to 1.0% of the total weight of the composition. ### Claim 8 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the quantity of the phosphonic acid derivative is from 0.1 to 0.5% of the total weight of the composition. ### Claim 9 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the quantity of the alcohol is not more than 20% of the total weight of the composition. ### Claim 10 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the quantity of the alcohol is not more than 10% of the total weight of the composition. ### Claim 11 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein the pH value of the composition is between 3.8 and 4.5. ### Claim 12 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, further comprising water. ### Claim 13 (depends on 1) The clear composition for stabilizing ascorbic acid derivative according to claim 1, wherein said ascorbic acid derivative is 3-O-ethyl ascorbic acid with the structure as following. ### Claim 14 A clear composition for stabilizing ascorbic acid derivative comprising: an ascorbic acid derivative, wherein a general formula of the ascorbic acid derivative is as the following, wherein R is selected from one of the group consisting of the following: C1-C20 alkyl group, C3-C20 cycloalkyl group, C1-C20 heterocycloalkyl group, C1-C20 alkoxy group, C2-C20 acyl group, C6-C20 aryl group, C1-C20 heterocyclic aromatic group, C3-C20 cycloalkenyl group; a buffer, wherein the buffer is employed to adjust pH value of the composition between 3.5 and 5.5; and a stabilizing agent consisted of phosphonic acid derivative and alcohol.