# US 2014/0155586 A1 · Compound Amycolamicin, Method for Producing the Same, and Use of the Same

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- Number: US 2014/0155586 A1
- Document ID: US20140155586A1
- Status: Published application
- Kind: A1
- Application number: 13/278,269
- Filed: 2011-10-21
- Published: 2014-06-05
- Earliest claimed: 2009-04-24
- Assignees: Microbial Chemistry Research Foundation
- Inventors: Masayuki Igarashi; Ryuichi Sawa; Yoshiko Homma
- Web page: https://patentgrep.com/patent/US20140155586A1

## CPC

- C07H 19/044: Pyrrole radicals
- A61P 31/04: Antibacterial agents
- C07D 405/14: containing three or more hetero rings
- C12N 1/205: Bacterial isolates
- C12P 17/16: containing two or more hetero rings {(thiamine open chain analogs C12P17/167, i.e. not condensed among themselves or through a common carbocyclic ring system)}
- C12P 19/44: Preparation of O-glycosides, e.g. glucosides {(polysaccharides and not substituted disaccharides C12P19/04, C12P19/12)}
- C12P 19/46: having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
- C12R 2001/01: Bacteria or Actinomycetales {; using bacteria or Actinomycetales}
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

A compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers.

## Claims

### Claim 1

A compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers.

### Claim 2

A method for producing a compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers, the method comprising:
culturing a microorganism belonging to the genus Amycolatopsis and capable of producing the compound having a structure expressed by the Structural Formula (1), the tautomers thereof, or the salts of the compound or the tautomers, and
isolating the compound having a structure expressed by the Structural Formula (1), the tautomers thereof, or the salts of the compound or the tautomers from a culture obtained from the culturing.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the microorganism is a microorganism of Amycolatopsis sp. MK575-fF5 strain deposited under accession number FERM P-21465.

### Claim 4

A microorganism,
wherein the microorganism belongs to the genus Amycolatopsis and is capable of producing a compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers.

### Claim 5 (depends on 4)

The microorganism according to claim 4, wherein the microorganism is a microorganism of Amycolatopsis sp. MK575-fF5 strain deposited under accession number FERM P-21465.

### Claim 6

An antibacterial agent comprising:
a compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers, serving as an active ingredient.