# US 2014/0155516 A1 · Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices

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- Number: US 2014/0155516 A1
- Document ID: US20140155516A1
- Status: Published application
- Kind: A1
- Application number: 14/062,442
- Filed: 2013-10-24
- Published: 2014-06-05
- Earliest claimed: 2006-02-08
- Assignees: Northwestern University
- Applicants: Northwestern University
- Inventors: Guillermo Ameer; Hongjin Qiu; Jian Yang
- Web page: https://patentgrep.com/patent/US20140155516A1

## CPC

- A61L 31/127: {containing fillers of phosphorus-containing inorganic materials}
- A61L 27/12: Phosphorus-containing materials, e.g. apatite
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/425: {of phosphorus containing material, e.g. apatite}
- A61L 27/427: {of other specific inorganic materials not covered by A61L27/422 or A61L27/425}
- A61L 27/46: with phosphorus-containing inorganic fillers
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 31/026: {Ceramic or ceramic-like structures, e.g. glasses}
- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- A61L 31/121: {having an inorganic matrix}
- A61L 31/123: {of phosphorus-containing materials, e.g. apatite}
- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material.

## Claims

### Claim at position 1

1-34. (canceled)

### Claim 35

A composition comprising a composite of:
a) a polyester comprising one or more linear aliphatic diol monomers and a citric acid monomer;
b) a bioceramic used for implantable tissue devices, wherein said composition comprises said bioceramic in an amount of 50 wt % or greater.

### Claim 36 (depends on 35)

The composition of claim 35, wherein the linear aliphatic diol monomer comprises between about 2 and about 20 carbons.

### Claim 37 (depends on 36)

The composition of claim 36, wherein the polyester comprises repeating units of the same linear aliphatic diol monomer.

### Claim 38 (depends on 37)

The composition of claim 37, wherein the linear aliphatic diol is 1,8-octanediol.

### Claim 39 (depends on 38)

The composition of claim 38, wherein the polyester is poly 1,8-octanediol co-citric acid.

### Claim 40 (depends on 36)

The composition of claim 36, wherein the polyester is poly 1,10 decanediol co-citric acid.

### Claim 41 (depends on 36)

The composition of claim 36, wherein the polyester comprises repeating units of different linear aliphatic diol monomers.

### Claim 42 (depends on 35)

The composition of claim 35, wherein said bioceramic is selected from the group consisting of calcium phosphate bioceramics, alumina based bioceramics; zirconia-based bioceramics; silica-based bioceramics, and pyrolytic carbon-based bioceramics.

### Claim 43 (depends on 42)

The composition of claim 42, wherein said bioceramic is a calcium phosphate bioceramic.

### Claim 44 (depends on 42)

The composition of claim 42, wherein said bioceramic is hydroxyapatite (HA).

### Claim 45 (depends on 42)

The composition of claim 42, wherein said bioceramic is a tricalcium phosphate.

### Claim 46 (depends on 35)

The composition of claim 35, wherein said bioceramic is present in an amount greater than 50 wt %.

### Claim 47 (depends on 35)

The composition of claim 35, wherein said bioceramic is present in an amount of 55 wt % or greater.

### Claim 48 (depends on 35)

The composition of claim 35, wherein said bioceramic is present in an amount of 55 wt % to 95 wt %.

### Claim 49 (depends on 35)

The composition of claim 35, wherein said bioceramic is present in an amount of 65 wt % to 90 wt %.

### Claim 50 (depends on 35)

The composition of claim 35, wherein said bioceramic is present in an amount of 70 wt % to 85 wt %.

### Claim 51 (depends on 35)

An implantable device comprising the composition of claim 35.

### Claim 52 (depends on 35)

The composition of claim 35, wherein the bioceramic comprises particles.

### Claim 53 (depends on 52)

The composition of claim 52, wherein the particles have a size from a nanometer to a micron.