# US 2014/0155491 A1 · Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof

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- Number: US 2014/0155491 A1
- Document ID: US20140155491A1
- Status: Published application
- Kind: A1
- Application number: 13/911,282
- Filed: 2013-06-06
- Published: 2014-06-05
- Earliest claimed: 2005-03-14
- Inventors: Robert Alonso; Peter A. Crooks; Mark A. Pimley
- Web page: https://patentgrep.com/patent/US20140155491A1

## CPC

- C07C 211/15: the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
- A61K 31/13: Amines {(A61K31/04 takes precedence)}
- A61K 31/131: acyclic
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/04: Antipruritics
- A61P 17/06: Antipsoriatics
- A61P 17/14: for baldness or alopecia
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y10T 428/13: Hollow or container type article [e.g., tube, vase, etc.]
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.

## Claims

### Claim 1

(canceled)

### Claim 2

(canceled)

### Claim 3

A composition comprising a Nitrogen Mustard Prodrug.

### Claim at position 4

-26. (canceled)