# US 2014/0155478 A1 · Antifungal compound and uses thereof

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- Number: US 2014/0155478 A1
- Document ID: US20140155478A1
- Status: Published application
- Kind: A1
- Application number: 14/095,757
- Filed: 2013-12-03
- Published: 2014-06-05
- Earliest claimed: 2012-12-04
- Assignees: The University of Hong Kong
- Applicants: The University of Hong Kong
- Inventors: Chaminda Jayampath SENEVIRATNE; Yi Tsun Richard KAO; Lakshman Perera SAMARANAYAKE; Kwok Yung YUEN; Dan YANG; Yu WANG; Sze Wah Sarah WONG
- Web page: https://patentgrep.com/patent/US20140155478A1

## CPC

- A61K 31/351: not condensed with another ring
- A01N 43/40: six-membered rings
- A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61P 31/10: Antimycotics
- A61P 31/18: for HIV
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.

## Claims

### Claim 1

A method for reducing growth of a fungus comprising contacting a fungal cell with a compound having a structure:
and a pharmaceutically acceptable carrier.

### Claim 2 (depends on 1)

The method of claim 1 wherein the fungal cell is a pathogenic yeast.

### Claim 3 (depends on 2)

The method of claim 2 wherein the fungal cell is Candida albicans, Pneumocystis carinii, Saccharomyces cerevisiae, Aspergillus nidulans, Kluyveromyces lactis, Schizosaccharomyces pombe, Streptomyces lasaliensis, Streptomyces hygroscopicus, Candida tropicalis, Candida dubliniensis, Candida parapsilosis, Candida kefyr, Candida guilliermondii, Candida inconspicua, Candida famata, Candida glabrata, Candida krusei, Candida lusitaniae, Cryptococcus neoformans, Coccidioides immitis, Hispolasma capsulatum or a combination thereof.

### Claim 4

A method of treating and preventing against fungal infections in a subject which comprises administering to the subject an effective amount of a compound having the structure:
and a pharmaceutically acceptable carrier.

### Claim 5 (depends on 4)

The method of claim 4 wherein the fungal cell is a pathogenic yeast.

### Claim 6 (depends on 5)

The method of claim 5 wherein the fungal infection is caused by C. albicans, C. glabrata, C. krusei, C. tropicalis, C. parapsilosis, C. neoformans, Aspergillus fumigates and Penicillium marneffei.

### Claim 7 (depends on 4)

The method of claim 4, wherein the subject is a human.

### Claim 8 (depends on 7)

The method of claim 7, wherein the subject is immunocompromised.

### Claim 9 (depends on 7)

The method of claim 7, wherein the subject had received chemotherapy.

### Claim 10 (depends on 7)

The method of claim 7, wherein the subject has AIDS.

### Claim 11 (depends on 7)

The method of claim 7, wherein the subject had received a transplant.

### Claim 12 (depends on 7)

The method of claim 7, wherein the subject has a central venous catheter.

### Claim 13 (depends on 7)

The method of claim 7, wherein the compound is administered via injection, topical route, oral route, nasal route, aerosol, or enema route.

### Claim 14

A medical device having a surface wherein at least a portion of the surface comprises a coating wherein the coating comprises a compound having a structure:

### Claim 15 (depends on 14)

A method of making a medical device of claim 14 comprising the steps of:
(a) providing a medical device having a surface; and
(b) applying a coating composition comprising a compound having a structure:
to at least a portion of the surface.