# US 2014/0155457 A1 · Method of Relieving, Improving, Preventing or Treating Xerostomia

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- Number: US 2014/0155457 A1
- Document ID: US20140155457A1
- Status: Published application
- Kind: A1
- Application number: 14/046,213
- Filed: 2013-10-04
- Published: 2014-06-05
- Earliest claimed: 2012-12-05
- Applicants: Sunbio Inc.
- Inventors: KWANG NHO; Min Jung AHN; Byung Hee SOHN; Chang Min HYUN; Jung Hun LEE
- Web page: https://patentgrep.com/patent/US20140155457A1

## CPC

- A61K 31/77: of oxiranes
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Provided is a method of relieving, improving, preventing or treating xerostomia including applying an oral cavity composition including a polyethylene glycol (PEG) derivative whose reactor is modified to form a covalent bond with an epithelial cell of the oral cavity. An oral moisturizing effect and moisture persistency are increased and the method is effective against xerostomia due to aging or disease.

## Claims

### Claim 1

A method of relieving, improving, preventing or treating xerostomia, comprising:
applying an oral cavity composition including a polyethylene glycol derivative whose reactor is modified to form a covalent bond with a polyethylene glycol derivative as an active component in an oral cavity.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the polyethylene glycol derivative has a reactor capable of forming a covalent bond with an amine group on an oral epithelial cell.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the polyethylene glycol derivative has a reactor selected from the group consisting of halogen, NH2, SH, CHO,

### Claim 4 (depends on 3)

The method according to claim 3, wherein the polyethylene glycol derivative is a compound represented by Formula 1 or 2:
where L1 and L2 are linkers which are each independently selected from the group consisting of a carbonyl bond
an ester bond
an ester sulfate bond
an orthoester bond (orthoester,
a urethane bond
an amide bond
an ester bond (—O—), a carbonate bond
a carbonyl sulfide bond
and a secondary amino bond
R1 and R2 are each independently selected from the group consisting of CH3O, OH, halogen, NH2, SH, CHO,
at least one of R1 and R2 is not CH3O or OH, a core is selected from the group consisting of
n is an integer from 10 to 2,000, m1 to m4 are each independently an integer from 0 to 3, p1 and p2 are each independently an integer from 0 to 1, and q is an integer from 3 to 8.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the polyethylene glycol derivative is a compound represented by Formula 1 or 2, which is selected from:

### Claim 6 (depends on 1, 2, 3, 4, 5)

The method according to any one of claims 1 to 5, wherein the oral cavity composition is formulated in the form of granules or powder.