# US 2014/0155448 A1 · Amino-acid-containing composition for enhancing recovery from muscle fatigue

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- Number: US 2014/0155448 A1
- Document ID: US20140155448A1
- Status: Published application
- Kind: A1
- Application number: 14/175,154
- Filed: 2014-02-07
- Published: 2014-06-05
- Earliest claimed: 2011-08-08
- Assignees: Ajinomoto Co., Inc.
- Applicants: Ajinomoto Co., Inc.
- Inventors: Hiroyuki Kato; Hisamine Kobayashi; Mayu Sugita; Hiromi Suzuki; Masako Mimura
- Web page: https://patentgrep.com/patent/US20140155448A1

## CPC

- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A23L 33/175: Amino acids
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Administering an amino acid-containing composition, containing the following amino acids (1)-(9), wherein the molar content ratio of each amino acid to the total content of the amino acids (1)-(9) falls within the following numerical ranges: (1) leucine 35-66%; (2) isoleucine 5.0-15%; (3) valine 5.0-15%; (4) threonine 7.0-14%; (5) lysine 8.0-16%; (6) methionine 2.0-10%; (7) histidine 0.1-3.5%; (8) phenylalanine 2.5-8.0%; and (9) tryptophan 0.1-2.0%, is effective for enhancing recovery from muscle fatigue.

## Claims

### Claim 1

An amino acid-containing composition for enhancing recovery from muscle fatigue, comprising the following amino acids (1)-(9), wherein
the molar content ratio of each amino acid to the total content of said amino acids (1)-(9) falls within the following numerical ranges:
(1) leucine 35-66%;
(2) isoleucine 5.0-15%;
(3) valine 5.0-15%;
(4) threonine 7.0-14%;
(5) lysine 8.0-16%;
(6) methionine 2.0-10%;
(7) histidine 0.1-3.5%;
(8) phenylalanine 2.5-8.0%; and
(9) tryptophan 0.1-2.0%.

### Claim 2 (depends on 1)

The amino acid-containing composition according to claim 1, wherein the muscle fatigue is muscle fatigue caused by muscle damage.

### Claim 3 (depends on 2)

The amino acid-containing composition according to claim 2, wherein the muscle damage is muscle damage after exercise.

### Claim 4 (depends on 3)

The amino acid-containing composition according to claim 3, wherein the muscle damage after exercise is muscle damage after eccentric contraction exercise.

### Claim 5 (depends on 1)

The amino acid-containing composition according to claim 1, wherein the enhanced recovery from muscle fatigue is prophylaxis and/or improvement of muscular pain.

### Claim 6 (depends on 1)

The amino acid-containing composition according to claim 1, wherein the enhanced recovery from muscle fatigue is prophylaxis and/or improvement of muscle weakness.

### Claim 7 (depends on 1)

The amino acid-containing composition according to claim 1, wherein the enhanced recovery from muscle fatigue is prophylaxis and/or improvement of muscle damage.

### Claim 8

A method of enhancing recovery from muscle fatigue, comprising administering to a subject in need thereof an effective amount of an amino acid-containing composition comprising the following amino acids (1)-(9), wherein
the molar content ratio of each amino acid to the total content of said amino acids (1)-(9) falls within the following numerical ranges:
(1) leucine 35-66%;
(2) isoleucine 5.0-15%;
(3) valine 5.0-15%;
(4) threonine 7.0-14%;
(5) lysine 8.0-16%;
(6) methionine 2.0-10%;
(7) histidine 0.1-3.5%;
(8) phenylalanine 2.5-8.0%; and
(9) tryptophan 0.1-2.0%.

### Claim 9 (depends on 8)

The method according to claim 8, wherein the muscle fatigue is muscle fatigue caused by muscle damage.

### Claim 10 (depends on 9)

The method according to claim 9, wherein the muscle damage is muscle damage after exercise.

### Claim 11 (depends on 10)

The method according to claim 10, wherein the muscle damage after exercise is muscle damage after eccentric contraction exercise.

### Claim 12 (depends on 8)

The method according to claim 8, wherein the enhanced recovery from muscle fatigue is prophylaxis and/or improvement of muscular pain.

### Claim 13 (depends on 8)

The method according to claim 8, wherein the enhanced recovery from muscle fatigue is prophylaxis and/or improvement of muscle weakness.

### Claim 14 (depends on 8)

The method according to claim 8, wherein the enhanced recovery from muscle fatigue is prophylaxis and/or improvement of muscle damage.