# US 2014/0155359 A1 · Formulation of transparent and nutritive microemulsions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155359 A1 - Document ID: US20140155359A1 - Status: Published application - Kind: A1 - Application number: 14/131,085 - Filed: 2012-07-13 - Published: 2014-06-05 - Earliest claimed: 2011-07-15 - Assignees: Prayon - Inventors: Guy Broze; Claire Pucci; Adeline Navarro - Web page: https://patentgrep.com/patent/US20140155359A1 ## CPC - A23L 2/52: Adding ingredients (adding preservatives A23B70/10) - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/15: Vitamins - A23L 33/155: Vitamins A or D - A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)} - A61P 3/02: Nutrients, e.g. vitamins, minerals - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A clear and nutritive microemulsion comprising an aqueous phase in which at least one liposoluble active ingredient is dispersed, a first surfactant included in the group consisting of non-ionic surfactants with a high HLB and non-ionic surfactants with medium HLBs; and a second surfactant, characterized in that said second surfactant is chosen from the group consisting of anionic surfactants which have an HLB ≧25. ## Claims ### Claim 1 Clear and nutritive microemulsion comprising an aqueous phase in which at least one liposoluble active ingredient is dispersed, a first surfactant included in the group consisting of non-ionic surfactants of high HLB and non-ionic surfactants of medium HLB; and a second surfactant, characterised in that said second surfactant is chosen from the group consisting of anionic surfactants having an HLB ≧25. ### Claim 2 (depends on 1) Microemulsion according to claim 1, further comprising a third surfactant from the group consisting of non-ionic surfactants of high HLB when the first surfactant is a non-ionic surfactant of medium HLB, or from the group consisting of non-ionic surfactants of medium HLB when the first surfactant is a non-ionic surfactant of high HLB. ### Claim 3 (depends on 1) Microemulsion according to claim 1, wherein said first and/or third non-ionic surfactant of high HLB is chosen from the group consisting of polyoxyethylene sorbitan esters, in particular sorbitan monododecanoate poly(oxy-1,2-ethanediyl) and alkyl polyglucosides (APGs). ### Claim 4 (depends on 1) Microemulsion according to claim 1, wherein said first and/or third non-ionic surfactant of medium HLB is chosen from the group consisting of sorbitan esters, in particular sorbitan laurate, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monopalmitate, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene glycol sorbitan laurate, hexaethylene glycol sorbitan monooleate, polyoxyethylene sorbitan stearate, decaglyceryl monooleate, decaglyceryl dioleate, polyoxyethylene sorbitan tristearate, monodehydrosorbitol monooleate, sorbitan monolaurate, sorbitan monopalmitate. ### Claim 5 (depends on 1) Microemulsion according to claim 1, wherein said second anionic surfactant is chosen from the group consisting of sodium dodecyl sulfate (SDS), alcohol sulfates, alcohol ethoxysulfates, alkylsulfonates and carboxylic acids and their salts, in particular gluconic acid and its derivatives. ### Claim 6 (depends on 1) Microemulsion according to claim 1, wherein said anionic surfactant is chosen from the group consisting of gluconic acid and its derivatives such as sodium, potassium, calcium and ferrous gluconate or glucono delta-lactone. ### Claim 7 (depends on 1) Microemulsion according to claim 1, wherein said liposoluble active ingredient is a vitamin chosen from the group consisting of vitamin D, vitamin K, vitamin A and vitamin E. ### Claim 8 (depends on 1) Microemulsion according to claim 1, further comprising an antioxidant, preferably chosen from the group consisting of caffeic acid, pomegranate plant extracts, rosemary plant extracts, rutin, vitamin E, polyphenols, preferably quercetin, and mixtures thereof. ### Claim 9 (depends on 1) Microemulsion according to claim 1, further comprising an oily phase. ### Claim 10 (depends on 1) Process for the production of a microemulsion according to claim 1, comprising the following steps: a) mixing, with stirring, at least two surfactants with at least one liposoluble active ingredient until a homogeneous solution is obtained; b) mixing, with stirring, said homogeneous solution with an aqueous phase until a microemulsion is obtained. ### Claim 11 (depends on 10) Process according to claim 10, further comprising dilution of said microemulsion with an aqueous medium such as water, for example distilled water and/or food-grade water, optionally in admixture with other additives, for example ortho-phosphoric acid and/or citric acid. ### Claim 12 (depends on 10) Process according to claim 10, further comprising an antioxidant, preferably chosen from the group consisting of caffeic acid, pomegranate plant extracts, rosemary plant extracts, rutin, vitamin E, polyphenols, preferably quercetin, and mixtures thereof. ### Claim 13 Method of making a clear and nutritive microemulsion, comprising: providing an anionic surfactant having an HLB ≧25. ### Claim 14 (depends on 13) Method according to claim 13, wherein said anionic surfactant is chosen from the group consisting of sodium dodecyl sulfate (SDS), alcohol sulfates, alcohol ethoxysulfates, alkylsulfonates and carboxylic acids and their salts, in particular gluconic acid and its derivatives. ### Claim 15 (depends on 13) Method according to claim 13, wherein said anionic surfactant is chosen from the group consisting of gluconic acid and its derivatives such as sodium, potassium, calcium and ferrous gluconate or glucono delta-lactone. ### Claim 15 (depends on 1) A clear and nutritive drink comprising a microemulsion according to claim 1. ### Claim 16 (depends on 14) A clear and nutritive drink according to claim 14, comprising an antioxidant. ### Claim 17 (depends on 15) A clear and nutritive drink according to claim 15, wherein the antioxidant is preferably chosen from the group consisting of caffeic acid, pomegranate plant extracts, rosemary plant extracts, rutin, vitamin E, polyphenols, preferably quercetin, and mixtures thereof.