# US 2014/0155346 A1 · Cosmetic and/or dermatological use of oligosaccharide compounds for preventing and treating stretch marks > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155346 A1 - Document ID: US20140155346A1 - Status: Published application - Kind: A1 - Application number: 14/131,794 - Filed: 2012-07-12 - Published: 2014-06-05 - Earliest claimed: 2011-07-13 - Assignees: Societe De Developpement Et De Recherche Industrielle; Laboratoires Urgo - Inventors: Laurent Apert; Marielle Bouschbacher - Web page: https://patentgrep.com/patent/US20140155346A1 ## CPC - A61K 8/60: Sugars; Derivatives thereof - A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof} - A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032) - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61Q 19/00: Preparations for care of the skin - A61Q 19/06: for countering cellulitis - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to a topical composition, in particular a cosmetic and/or dermatological composition, to be used for preventing and/or treating stretch marks, including, in a physiologically acceptable medium, an effective amount of at least one synthetic polysulfated oligosaccharide having 1 to 4 glycose units, the salts thereof, and/or the derivatives thereof. The invention also relates to a cosmetic method, in particular for treating stretch marks, including at least one step of applying said composition to the skin. ## Claims ### Claim 1 A method for preventing and/or treating stretch marks, comprising the administration to a subject in need thereof of a cosmetic and/or dermatological topical composition comprising in a physiologically acceptable vehicle, at least an effective amount of at least one of synthetic polysulfated oligosaccharide having 1 to 4 monosaccharide units, salts and/or derivatives thereof. ### Claim 2 (depends on 1) The method as claimed in claim 1, wherein the composition comprises at least synthetic polysulfated oligosaccharide having 1 or 2 monosaccharide units selected from the pentoses and the hexoses, as well as the salts and/or derivatives of these compounds. ### Claim 3 (depends on 1) The method as claimed in claim 1, wherein said synthetic polysulfated oligosaccharide having 1 or 2 monosaccharide units is selected from potassium salt of sucrose octasulfate, silver salt of sucrose octasulfate, the hydroxyaluminum complex of sucrose octasulfate and mixtures thereof. ### Claim 4 (depends on 1) The method as claimed in claim 1, wherein said synthetic polysulfated oligosaccharide is present at a content between 0.1 and 50 wt %, relative to the total weight of the composition. ### Claim 5 (depends on 1) The method as claimed in claim 1, wherein said synthetic polysulfated oligosaccharide is present in a content such that the amount salted-out on the stretch marks is between 0.001 g/l and 50 g/l. ### Claim at position 6 6-17. (canceled) ### Claim 18 (depends on 1) The method as claimed in claim 1, wherein said synthetic polysulfated oligosaccharide is present in a content such that the amount salted-out on the stretch marks is between 0.01 and 10 g/l. ### Claim 19 (depends on 1) The method as claimed in claim 1, wherein the composition comprises one or more other active substance(s) selected from antibacterials, antiseptics, antifungals, anti-inflammatories, active substances promoting healing and/or restructuring of the skin, antipruritics, UV filters, soothing agents, hydrating agents, depigmenting agents, keratolytic agents, antivirals, analgesics, anesthetics, vitamins, and mixtures thereof. ### Claim 20 (depends on 19) The method as claimed in claim 19, wherein the active substance is selected from the active substances promoting healing and/or restructuring of the skin, and notably hyaluronic acid. ### Claim 21 (depends on 1) The method as claimed in claim 1, wherein the composition is in the form of solutions (aqueous, aqueous-alcoholic or oily), dispersions (lotion or serum type), emulsions of liquid or semiliquid consistency (milk type), suspensions or emulsions (cream type), aqueous or lipophilic gel, microemulsions, microcapsules, microparticles, vesicular dispersions of the ionic and/or nonionic type, nonabsorbent interface dressings. ### Claim 22 (depends on 1) The method as claimed in claim 1, wherein the composition is in the form of an oil-in-water emulsion cream, comprising: 0.1 to 5% of potassium salt of sucrose octasulfate KSOS, 40 to 60 wt % of water, 20 to 40 wt % of at least one oil, 1 to 10 wt % of at least one surfactant, 0 to 10 wt % of at least one wax, 0 to 20 wt % of active substances, 0 to 2 wt % of preservatives, 0 to 5 wt % of thickeners. ### Claim 23 (depends on 1) The method as claimed in claim 1, wherein the composition is in the form of a film. ### Claim 24 (depends on 23) The method as claimed in the claim 23, wherein it comprises one or more film-forming polymer(s) at a content ranging from 10 to 95 wt %, relative to the total weight of the film. ### Claim 25 (depends on 23) The method as claimed in the claim 23, wherein it comprises one or more film-forming polymer(s) at a content ranging from 20 to 70 wt %, relative to the total weight of the film. ### Claim 26 (depends on 23) The method as claimed in the claim 23, wherein it comprises one or more film-forming polymer(s) at a content ranging from 30 to 60 wt %, relative to the total weight of the film. ### Claim 27 (depends on 23) The method as claimed in claim 23, wherein the composition further comprises a polysaccharide thickener. ### Claim 28 (depends on 23) The method as claimed in claim 23, wherein the composition is in the form of an anhydrous water-soluble film comprising (i) at least one synthetic polysulfated oligosaccharide, (ii) at least one water-soluble or water-dispersible film-forming polymer and (iii) at least one alkoxylated polydimethylsiloxane derivative. ### Claim 29 (depends on 23) The method as claimed in claim 23, wherein the composition is in the form of a solvent-based filmogel composition comprising: 0.01 to 5% of potassium salt of sucrose octasulfate KSOS 15 to 50 wt % of ethanol, 40 to 60% of ethyl acetate, 5 to 20 wt % of film-forming polymer of the nitrocellulose type, 5 to 20% of plasticizer castor oil, 0 to 2 wt % of preservatives, 0 to 5 wt % of thickeners. ### Claim 30 (depends on 23) The method as claimed in claim 23, wherein the composition is in the form of a water-based filmogel composition comprising: 0.1 to 5% of potassium salt of sucrose octasulfate KSOS, 70 to 99 wt % of water, 0 to 10 wt % of active substances, 0 to 2 wt % of preservatives, 0 to 5 wt % of thickeners. ### Claim 31 (depends on 1) The method as claimed in claim 1, for treating stretch marks or wounds in a subject having a predisposition to the development of stretch marks. ### Claim 32 (depends on 1) A cosmetic method comprising at least one step in which a topical composition as claimed in claim 1 is applied on the skin.