# US 2014/0155342 A1 · Patch containing diclofenac and thiocolchicoside

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- Number: US 2014/0155342 A1
- Document ID: US20140155342A1
- Status: Published application
- Kind: A1
- Application number: 14/232,703
- Filed: 2012-06-15
- Published: 2014-06-05
- Earliest claimed: 2011-07-20
- Assignees: Epifarma Srl
- Inventors: Giuseppe Irianni
- Web page: https://patentgrep.com/patent/US20140155342A1

## CPC

- A61K 9/7023: {Transdermal patches and similar drug-containing composite devices, e.g. cataplasms (galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006)}
- A61K 9/7061: {Polyacrylates}
- A61K 31/196: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 19/04: for non-specific disorders of the connective tissue
- A61P 19/08: for bone diseases, e.g. rachitism, Paget's disease
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a patch for the transdermal release of diclofenac or a pharmaceutically acceptable salt thereof, in particular diethylamine salt, and thiocolchicoside.

## Claims

### Claim 1

Patch containing, dispersed in an adhesive matrix, diclofenac or a pharmaceutically acceptable salt thereof, thiocolchicoside and optionally, pharmaceutically acceptable excipients.

### Claim 2 (depends on 1)

Patch according to claim 1, wherein the adhesive matrix comprises:
a copolymer of acrylic or methacrylic acid or its esters, component A;
a cationic copolymer obtained by copolymerisation of dimethylaminoethyl-methacrylate and methacrylic acid neutral esters comprising methyl, ethyl and butyl esters, component B; and
a cationic copolymer obtained by copolimerisation of ethyl acrylate, methyl methacrylate and (trimethylammonium)methyl-methacrylate, component C.

### Claim 3 (depends on 2)

Patch according to claim 2, wherein the total quantity of said components A and B in the adhesive matrix ranges from 50 to 90% of the total weight of the dried adhesive matrix.

### Claim 4 (depends on 2)

Patch according to claim 2, wherein said component C is present in amounts ranging from 0.1 to 10% of the total weight of the dried adhesive matrix.

### Claim 5 (depends on 4)

Patch according to claim 4, wherein diclofenac is in the form of diethylamine salt.

### Claim 6 (depends on 1)

Patch according to claim 1, wherein diclofenac or a salt thereof are present in amounts ranging from 1 to 15% by weight of the total dried adhesive matrix and thiocolchicoside is present in amounts ranging from 0.1 to 5% by weight of the total adhesive matrix.

### Claim 7 (depends on 1)

Patch according to claim 1, wherein diclofenac is present as diethylamine salt in amounts ranging from 5 to 10% and thiocolchicoside is present in amounts ranging from 0.1 to 1%, wherein said percentages relate to the weight of the dried adhesive matrix.

### Claim 8 (depends on 1)

Patch according to claim 1, wherein the adhesive matrix also contains stabilisers, solubilisers or substances designed to modify the release rate or increase the transdermal absorption of the active ingredients it contains.

### Claim 9 (depends on 1)

Method of locally treating joint, muscle, tendon or ligament pain and inflammation of rheumatic or traumatic origin with the patch of claim 1.

### Claim 10 (depends on 9)

Method of claim 9, wherein said joint, muscle, tendon or ligament pain and inflammation of rheumatic or traumatic origin comprises articular and extra-articular rheumatic inflammatory disorders, acute and chronic lumbosciatic pain, cervical neuralgia, torticollis, and post-traumatic and post-surgical pain syndromes.