# US 2014/0155335 A1 · Elastin protective polyphenolics and methods of using the same

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2014/0155335 A1
- Document ID: US20140155335A1
- Status: Published application
- Kind: A1
- Application number: 14/150,742
- Filed: 2014-01-08
- Published: 2014-06-05
- Earliest claimed: 2005-03-29
- Assignees: The Hospital for Sick Children; Human Matrix Sciences, LLC
- Applicants: The Hospital for Sick Children; Human Matrix Sciences, LLC
- Inventors: Thomas MITTS; Felipe JIMENEZ; Aleksander HINEK
- Web page: https://patentgrep.com/patent/US20140155335A1

## CPC

- A61K 31/7034: attached to a carbocyclic compound, e.g. phloridzin
- A61K 8/02: characterised by special physical form
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/60: Sugars; Derivatives thereof
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61K 31/7028: Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/91: Injection
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

## Claims

### Claim 1

A method for protecting elastin fibers from degradation comprising administering to the skin in need thereof a composition comprising from about 1 μg to about 10 μg of a polyphenolic compound.

### Claim 2

A method for reducing photo-induced damage to the skin comprising administering to the skin in need thereof a composition comprising from about 1 μg to about 10 μg of a polyphenolic compound.

### Claim 3

A method for protecting dermal tissue from damage by irradiation comprising administering to the skin in need thereof a composition comprising from about 1 μg to about 10 μg of a polyphenolic compound.