# US 2014/0155320 A1 · Use of storage stable viscous phospholipid depot to treat wounds > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0155320 A1 - Document ID: US20140155320A1 - Status: Published application - Kind: A1 - Application number: 13/824,119 - Filed: 2011-10-18 - Published: 2014-06-05 - Earliest claimed: 2010-10-22 - Assignees: Dr. Reddy's Laboratories, Inc. - Inventors: Hailiang Chen; Andrew Xian Chen; Dushyanth Surakanti; Franklin Omuku - Web page: https://patentgrep.com/patent/US20140155320A1 ## CPC - A61K 38/14: Peptides containing saccharide radicals; Derivatives thereof {, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin} - A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} - A61K 31/7036: having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins - A61K 31/7052: having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 17/00: Drugs for dermatological disorders - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics - A61P 31/04: Antibacterial agents - A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention provides a method of preventing and/or treating a wound infection by introducing to a wound a clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of vancomycin, gentamicin, and a mixture thereof, water, a phospholipid, an oil, a pH adjusting agent, and a viscosity modifying agent, wherein the water present in the viscous depot is no more than about 4 wt %, no more than about 2 wt %, or no more than about 0.5 wt % of water relative to the total weight of the depot. ## Claims ### Claim 1 A method of preventing and/or treating a wound infection comprising administering to said wound a clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of a pharmaceutically acceptable salt of vancomycin, gentamicin, and a mixture thereof, water, a phospholipid, an oil, a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the viscous depot is no more than about 2 wt % relative to the total weight of the depot. ### Claim 2 (depends on 1) The method according to claim 1, wherein the wound is selected from the group consisting of chronic wound, acute wound, surgical wound, orthopedic wound, traumatic wound, combat wound and any combination thereof. ### Claim 3 (depends on 2) The method according to claim 2, wherein the orthopedic wound is an injury to the musculoskeletal system, extremities including pelvis, spine and associated structures, and any combination thereof. ### Claim 4 (depends on 2) The method according to claim 2, wherein the traumatic wound is selected from an open wound to head, face, chest, abdomen, extremities including pelvis, and/or external and/or injuries with torn and irregular edge with presence of foreign matter and/or non-viable tissue fragments, such as laceration, abrasions, puncture wounds, penetration wounds, and. any combination thereof. ### Claim 5 (depends on 2) The method according to claim 2, wherein the combat wound is selected from injuries inflicted by an explosive device and/or a weapon, gunshot wound, and any combination thereof. ### Claim 6 (depends on 1) The method according to claim 1, which further comprise cleaning the wound to substantially remove a foreign material and/or non-viable tissue; and closing the wound. ### Claim 7 (depends on 6) The method according to claim 6, wherein the step of closing the wound is performed using a suture, metal clips, staples or adhesive strips. ### Claim 8 (depends on 1) The method according to claim 1 which comprises administering the depot to a wound and using a vacuum-assisted wound closure system to the wound. ### Claim 9 (depends on 1) The method according to of claim 1 which comprises cleaning the wound to substantially remove a foreign material and/or non-viable tissue; using a vacuum-assisted wound closure system to the wound; introducing the depot to a wound; and closing the wound. ### Claim 10 (depends on 1) The method according to claim 1 which comprises administering the depot either before, during or after closing of the wound using a suture, metal clip, staple, dressing, bandages and/or adhesive strips/tapes. ### Claim 11 A clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of a pharmaceutically acceptable salt of vancomycin, gentamicin, and a mixture thereof, water, a phospholipid, an oil, a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the viscous depot is no more than about 2 wt % relative to the total weight of the depot for the prevention and/or treatment of a wound. ### Claim 12 (depends on 11) The depot according to claim 11, wherein the wound is selected from the group consisting of chronic wound, acute wound, surgical wound, orthopedic wound, traumatic wound, combat wound and any combination thereof. ### Claim 13 (depends on 12) The depot according to claim 12, wherein the orthopedic wound is an injury to the musculoskeletal system, extremities including pelvis, spine and associated structures, and any combination thereof. ### Claim 14 (depends on 12) The depot according to claim 12, wherein the traumatic wound is selected from an open wound to head, face, chest, abdomen, extremities including pelvis, and/or external and/or injuries with torn and irregular edge with presence of foreign matter and/or non-viable tissue fragments, such as laceration, abrasions, puncture wounds, penetration wounds, and any combination thereof. ### Claim 15 (depends on 12) The depot according to claim 12, wherein the combat wound is selected from injuries inflicted by an explosive device and/or a weapon, gunshot wound, and any combination thereof. ### Claim 16 (depends on 11) The depot according to claim 11, which further comprise cleaning the wound to substantially remove a foreign material and/or non-viable tissue; and closing the wound. ### Claim 17 (depends on 16) The depot according to claim 16, wherein the step of closing the wound is performed using a suture, metal clips, staples or adhesive strips. ### Claim 18 (depends on 11) The depot according claim 11 which comprises administering the depot to a wound and using a vacuum-assisted wound closure system to the wound. ### Claim 19 (depends on 11) The depot according to claim 11 which comprises cleaning the wound to substantially remove a foreign material and/or non-viable tissue; using a vacuum-assisted wound closure system to the wound; introducing the depot to a wound; and closing the wound. ### Claim 20 (depends on 11) The depot according to claim 11 which comprises administering the depot either before, during or after closing of the wound using a suture, metal clip, staple, dressing, bandages and/or adhesive strips/tapes.