# US 2014/0155294 A1 · Cell chip, cell slice sample and manufacturing method thereof

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- Number: US 2014/0155294 A1
- Document ID: US20140155294A1
- Status: Published application
- Kind: A1
- Application number: 13/770,910
- Filed: 2013-02-19
- Published: 2014-06-05
- Earliest claimed: 2012-12-05
- Assignees: Samsung Electro-Mechanics Co., Ltd.
- Applicants: Samsung Electro-Mechanics Co., Ltd.
- Inventors: Dong Woo LEE; Bo Sung KU
- Web page: https://patentgrep.com/patent/US20140155294A1

## CPC

- G01N 1/36: Embedding or analogous mounting of samples
- C12N 11/00: Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- G01N 1/06: providing a thin slice, e.g. microtome
- G01N 2001/368: {Mounting multiple samples in one block, e.g. TMA [Tissue Microarrays]}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

There is provided a cell chip, a cell slice sample, and a manufacturing method thereof. The cell chip includes a plate member; biomaterials attached to one surface of the plate member; and a solidifiable material formed on one surface of the plate member to form a layer including the biomaterials.

## Claims

### Claim 1

A cell chip comprising:
a plate member;
biomaterials attached to one surface of the plate member; and
a solidifiable material formed on one surface of the plate member to form a layer including the biomaterials.

### Claim 2 (depends on 1)

The cell chip of claim 1, wherein the plate member includes a hydrophilic region to which the biomaterials are attached and a hydrophobic region blocking the biomaterials from being attached thereto.

### Claim 3 (depends on 2)

The cell chip of claim 2, wherein the hydrophobic region is formed to enclose the hydrophilic region.

### Claim 4 (depends on 1)

The cell chip of claim 1, wherein the plate member includes protrusions to which the biomaterials are attached.

### Claim 5 (depends on 4)

The cell chip of claim 4, wherein end surfaces of the protrusions are coated with a hydrophilic material so that the biomaterials are easily attached thereto.

### Claim 6 (depends on 1)

The cell chip of claim 1, wherein the solidifiable material includes a paraffin component.

### Claim 7 (depends on 1)

The cell chip of claim 1, wherein the biomaterials are sampled from at least one kind of sample.

### Claim 8

A cell slice sample comprising:
a slice formed of a solidifiable material; and
at least one kind of biomaterials formed on the slice.

### Claim 9 (depends on 8)

The cell slice sample of claim 8, wherein the slice is formed of a paraffin component.

### Claim 10 (depends on 8)

The cell slice sample of claim 8, wherein the biomaterials are provided at predetermined intervals in first and second directions of the slice.

### Claim 11

A method of manufacturing a cell chip, comprising:
attaching biomaterials to one surface of a plate member; and
forming a solidifiable layer on one surface of the plate member, the solidifiable layer accommodating the biomaterials therein and being formed of a solidifiable material.

### Claim 12 (depends on 11)

The method of claim 11, further comprising:
applying a hydrophobic material to the plate member; and
partially applying a hydrophilic material to the hydrophobic material.

### Claim 13

A method of manufacturing a cell chip, comprising:
attaching biomaterials to protrusions formed on one surface of a plate member; and
forming a solidifiable layer on one surface of the plate member, the solidifiable layer accommodating the biomaterials therein and being formed of a solidifiable material.

### Claim 14 (depends on 13)

The method of claim 13, further comprising:
applying a hydrophobic material to the plate member; and
partially applying a hydrophilic material to the hydrophobic material.

### Claim 15 (depends on 13)

The method of claim 13, wherein the attaching of the biomaterials includes immersing the protrusions of the plate member in grooves in which the biomaterials are accommodated.

### Claim 16

A method of manufacturing a cell slice sample, comprising:
attaching biomaterials to one surface of a plate member;
forming a solidifiable layer on one surface of the plate member, the solidifiable layer accommodating the biomaterials therein and being formed of a solidifiable material; and
cutting the solidifiable layer into a slice.

### Claim 17 (depends on 16)

The method of claim 16, further comprising:
applying a hydrophobic material to the plate member; and
partially applying a hydrophilic material to the hydrophobic material.

### Claim 18

A method of manufacturing a cell slice sample, comprising:
attaching biomaterials to protrusions formed on one surface of a plate member;
forming a solidifiable layer on one surface of the plate member, the solidifiable layer accommodating the biomaterials therein and being formed of a solidifiable material; and
cutting the solidifiable layer into a slice.

### Claim 19 (depends on 18)

The method of claim 18, further comprising applying a hydrophobic material to the protrusions.