# US 2014/0154793 A1 · Cell analyzer

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2014/0154793 A1
- Document ID: US20140154793A1
- Status: Published application
- Kind: A1
- Application number: 14/141,211
- Filed: 2013-12-26
- Published: 2014-06-05
- Earliest claimed: 2011-06-27
- Assignees: Sysmex Corporation
- Applicants: Sysmex Corporation
- Inventors: Takamichi NAITO; Takeo SAITOU
- Web page: https://patentgrep.com/patent/US20140154793A1

## CPC

- G01N 21/6486: {Measuring fluorescence of biological material, e.g. DNA, RNA, cells (G01N21/6428 takes precedence)}
- G01N 15/1429: Signal processing
- G01N 15/1433: using image recognition
- G01N 15/147: {the analysis being performed on a sample stream}
- G01N 2015/1472: {with colour}
- G01N 2015/1488: {Methods for deciding}
- G01N 2015/1497: {Particle shape}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A cell analyzer includes a flow cell through which a sample containing a cell flows; an imaging unit that captures the cell contained in the sample flowing through the flow cell; a cell image storage unit that stores a cell image captured by the imaging unit; a light source that irradiates the sample flowing through the flow cell with light; a light receiving unit that receives light from the cell irradiated with the light from the light source and outputs a signal corresponding to a light receiving amount; a waveform data storage unit that stores data indicating change in the light receiving amount obtained based on the output signal; a display unit; and a control unit that controls the display unit to display the cell image and a graph representing a waveform of data for the cell in the cell image and/or a marker corresponding to the data.

## Claims

### Claim 1

A cell analyzer comprising:
a flow cell through which a sample containing a cell flows;
an imaging unit that captures the cell contained in the sample flowing through the flow cell;
a cell image storage unit that stores a cell image captured by the imaging unit;
a light source that irradiates the sample flowing through the flow cell with light;
a light receiving unit that receives light from the cell irradiated with the light from the light source and outputs a signal corresponding to a light receiving amount;
a waveform data storage unit that stores data indicating change in the light receiving amount obtained based on the output signal;
a display unit; and
a control unit that controls the display unit to display the cell image and a graph representing a waveform of data for the cell in the cell image and/or a marker corresponding to the data.

### Claim 2 (depends on 1)

The cell analyzer according to claim 1, wherein the control unit controls the display unit to display the cell image and the graph and/or the marker on the same screen.

### Claim 3 (depends on 2)

The cell analyzer according to claim 2, wherein the control unit executes position adjustment of adjusting a position of one of the cell image and the graph and/or the marker according to a position of the other one, and controls the display unit to display the cell image and the graph and/or the marker after the position adjustment.

### Claim 4 (depends on 1)

The cell analyzer according to claim 1, wherein the control unit executes size adjustment of adjusting a size of one of the cell image and the graph and/or the marker according to a size of the other one, and controls the display unit to display the cell image and the graph and/or the marker after the size adjustment.

### Claim 5 (depends on 1)

The cell analyzer according to claim 1, wherein the control unit controls the display unit to display a set of the cell image and the graph and/or the marker in a list.

### Claim 6 (depends on 1)

The cell analyzer according to claim 1, wherein the marker is a color displayed with a density corresponding to the light receiving amount.

### Claim 7 (depends on 6)

The cell analyzer according to claim 6, wherein the data includes data indicating temporal change of a fluorescence intensity for a predetermined cell; and
the marker is a color displayed with a density corresponding to the fluorescence intensity.

### Claim 8 (depends on 6)

The cell analyzer according to claim 6, wherein the data includes data indicating temporal change of a scattered light intensity for a predetermined cell; and
the marker is a color displayed with a density corresponding to the scattered light intensity.

### Claim 9 (depends on 1)

The cell analyzer according to claim 1, wherein the data includes data indicating temporal change of a fluorescence intensity for a predetermined cell; and
the marker is given to a range in which the fluorescence intensity is greater than or equal to a predetermined value.

### Claim 10 (depends on 9)

The cell analyzer according to claim 9, wherein the range in which the fluorescence intensity is greater than or equal to the predetermined value is information reflecting a position of a nucleus in the predetermined cell.

### Claim 11 (depends on 9)

The cell analyzer according to claim 9, wherein the marker is a color displayed in a range in which the fluorescence intensity is greater than or equal to the predetermined value.

### Claim 12 (depends on 1)

The cell analyzer according to claim 1, wherein the data includes data indicating temporal change of a scattered light intensity for a predetermined cell; and
the marker is given to a range in which the scattered light intensity is greater than or equal to a predetermined value.

### Claim 13 (depends on 12)

The cell analyzer according to claim 12, wherein the range in which the scattered light intensity is greater than or equal to the predetermined value is information reflecting a size of the predetermined cell.

### Claim 14 (depends on 12)

The cell analyzer according to claim 12, wherein the marker is a color displayed in a range in which the scattered light intensity is greater than or equal to the predetermined value.

### Claim 15 (depends on 1)

The cell analyzer according to claim 1, wherein the control unit controls the display unit to display the marker and the cell image in an overlapping manner.

### Claim 16 (depends on 1)

The cell analyzer according to claim 1, wherein the control unit controls the display unit to display a plurality of markers in an overlapping manner.

### Claim 17 (depends on 3)

The cell analyzer according to claim 3, wherein the control unit executes size adjustment of adjusting a size of one of the cell image and the graph and/or the marker according to a size of the other one, and controls the display unit to display the cell image and the graph and/or the marker after the size adjustment.

### Claim 18 (depends on 2)

The cell analyzer according to claim 2, wherein the marker is a color displayed with a density corresponding to the light receiving amount.

### Claim 19 (depends on 4)

The cell analyzer according to claim 4, wherein the marker is a color displayed with a density corresponding to the light receiving amount.

### Claim 20 (depends on 5)

The cell analyzer according to claim 5, wherein the marker is a color displayed with a density corresponding to the light receiving amount.
