# US 2014/0154730 A1 · Method for stabilization of fluid biological samples

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- Number: US 2014/0154730 A1
- Document ID: US20140154730A1
- Status: Published application
- Kind: A1
- Application number: 14/131,721
- Filed: 2012-07-09
- Published: 2014-06-05
- Earliest claimed: 2011-07-13
- Assignees: Denator AB
- Inventors: Olof Sköld; David Zee-Berg; Karl Sköld; Mats Borén
- Web page: https://patentgrep.com/patent/US20140154730A1

## CPC

- G01N 1/30: Staining; Impregnating {; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis}
- G01N 1/2813: {Producing thin layers of samples on a substrate, e.g. smearing, spinning-on (G01N1/30 takes precedence)}
- G01N 1/44: Sample treatment involving radiation, e.g. heat
- G01N 2001/2826: {Collecting by adsorption or absorption}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention relates to a method for rapid stabilization of fluid biological samples, such as blood samples. More specifically, the method is based on heat stabilization of the fluid biological sample absorbed in a matrix.

## Claims

### Claim 1

A method for the stabilization of fluid biological samples, said method comprising the steps of:
(a) applying a sample of the fluid in a matrix of a porous material; and
(b) rapid heating of the sample in the matrix.

### Claim 2 (depends on 1)

The method according to claim 1 , further comprising the step:
(c) drying the sample in the matrix.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the fluid biological sample is selected from the group consisting of blood, plasma, serum, saliva, urine, synovial and cerebrospinal fluid, and tissue homogenates.

### Claim 4 (depends on 3)

The method according to claim 3, wherein the fluid biological sample is a blood sample.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the matrix is composed of a material selected from the group consisting of cellulose, cellulose based materials, glass fibre media, plastic polymers, mixed polymers, polyamides, and metals.

### Claim 6 (depends on 2)

The method according to claim 2, wherein the fluid biological sample is selected from the group consisting of blood, plasma, serum, saliva, urine, synovial and cerebrospinal fluid, and tissue homogenates.

### Claim 7 (depends on 6)

The method according to claim 6, wherein the fluid biological sample is a blood sample.

### Claim 8 (depends on 2)

The method according to claim 2, wherein the matrix is composed of a material selected from the group consisting of cellulose, cellulose based materials, glass fibre media, plastic polymers, mixed polymers, polyamides, and metals.

### Claim 9 (depends on 3)

The method according to claim 3, wherein the matrix is composed of a material selected from the group consisting of cellulose, cellulose based materials, glass fibre media, plastic polymers, mixed polymers, polyamides, and metals.

### Claim 10 (depends on 4)

The method according to claim 4, wherein the matrix is composed of a material selected from the group consisting of cellulose, cellulose based materials, glass fibre media, plastic polymers, mixed polymers, polyamides, and metals.