# US 2014/0154508 A1 · Porogen compositions, methods of making and uses

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- Number: US 2014/0154508 A1
- Document ID: US20140154508A1
- Status: Published application
- Kind: A1
- Application number: 14/174,299
- Filed: 2014-02-06
- Published: 2014-06-05
- Earliest claimed: 2010-05-11
- Assignees: Allergan, Inc.
- Applicants: Allergan, Inc.
- Inventors: Futian Liu; Nicholas J. Manesis; Xiaojie Yu; Athene Wan Chie Chan
- Web page: https://patentgrep.com/patent/US20140154508A1

## CPC

- A61L 31/10: Macromolecular materials
- A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- A61F 2/12: Mammary prostheses
- A61L 2430/04: for mammary reconstruction
- Y10T 428/2989: Microcapsule with solid core [includes liposome]
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

## Claims

### Claim 1

A porogen composition useful for making a porous material and/or a textured surface, the porogen composition comprising:
a) a shell material; and
b) a core material;
wherein the shell material has a melting temperature that is lower than a melting temperature of the core material.

### Claim 2 (depends on 1)

The porogen composition of claim 1, wherein the shell material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a surfactant and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof.

### Claim 3 (depends on 1)

The porogen composition of claim 1, wherein the core material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof.

### Claim 4 (depends on 1)

The porogen composition of claim 1, wherein the core material is a sugar.

### Claim 5 (depends on 1)

The porogen composition of claim 1, wherein the shell material is a polymer.

### Claim 6 (depends on 1)

The porogen composition of claim 1, wherein the core material is a sugar and the shell material is a polymer.

### Claim 7 (depends on 1)

The porogen composition of claim 1 wherein the core material comprises sucrose.

### Claim 8 (depends on 1)

The porogen composition of claim 1 wherein the core material comprises a starch.

### Claim 9 (depends on 1)

The porogen composition of claim 1 wherein the shell material is polyethylene glycol.

### Claim 10 (depends on 9)

The porogen composition of claim 9 wherein the core material is a sugar.

### Claim 11

A porogen composition useful for making a porous material and/or a textured surface, the porogen composition comprising:
a) a shell material; and
b) a core material;
wherein under a given physical or physicochemical treatment the shell material is fusible and the core material is non-fusible.

### Claim 12 (depends on 11)

The porogen composition of claim 11, wherein the shell fusion occurs by a physical state change from solid phase to liquid or rubbery phase.

### Claim 13 (depends on 11)

The porogen composition of claim 11, wherein the physicochemical treatment is heat or an organic solvent.

### Claim 14 (depends on 11)

The porogen composition of claim 11, wherein the core material is a sugar.

### Claim 15 (depends on 11)

The porogen composition of claim 11, wherein the shell material is a polymer.

### Claim 16 (depends on 11)

The porogen composition of claim 11, wherein the core material is a sugar and the shell material is a polymer.

### Claim 17 (depends on 11)

The porogen composition of claim 11, wherein the core material comprises sucrose.

### Claim 18 (depends on 11)

The porogen composition of claim 11, wherein the core material comprises a starch.

### Claim 19 (depends on 11)

The porogen composition of claim 11, wherein the shell material is polyethylene glycol.

### Claim 20 (depends on 19)

The porogen composition of claim 19 wherein the core material is a sugar.
