# US 2014/0154400 A1 · Method of drying bioabsorbable coating over stents

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- Number: US 2014/0154400 A1
- Document ID: US20140154400A1
- Status: Published application
- Kind: A1
- Application number: 14/155,217
- Filed: 2014-01-14
- Published: 2014-06-05
- Earliest claimed: 2000-12-28
- Assignees: Abbott Cardiovascular Systems Inc.
- Applicants: Abbott Cardiovascular Systems Inc.
- Inventors: Yung-Ming Chen; Jason Van Sciver; Syed F.A. Hossainy; Stephen D. Pacetti
- Web page: https://patentgrep.com/patent/US20140154400A1

## CPC

- B29C 65/76: Making non-permanent or releasable joints
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/86: Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- B05D 1/38: with intermediate treatment (intermediate treatment per se B05D3/00)
- B05D 3/0473: {for heating, e.g. vapour heating}
- B29C 65/10: using hot gases {(e.g. combustion gases) or flames coming in contact with at least one of the parts to be joined}
- A61F 2210/0004: bioabsorbable
- A61F 2210/0076: multilayered, e.g. laminated structures
- A61F 2240/001: Designing or manufacturing processes
- A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body
- A61F 2310/00389: The prosthesis being coated or covered with a particular material
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 2420/02: Methods for coating medical devices
- B05D 3/0254: {After-treatment}
- B29K 2067/046: {PLA, i.e. polylactic acid or polylactide}
- B29K 2105/258: {Tubular}
- B29L 2031/7534: {Cardiovascular protheses}
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B29K: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR {MOULDS, } REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES

## Abstract

Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

## Claims

### Claim at position 1

1-9. (canceled)

### Claim 10

A method of coating a stent, comprising:
applying a composition to a stent substrate, the composition including a polymer component and a solvent;
performing a thermal treatment on the applied composition, wherein the thermal treatment removes solvent from the applied composition; and
repeating the applying and the thermal treatment one or more times to form a coating comprising less than 2 wt % solvent,
wherein a duration of each of the thermal treatments is less than 60 s.

### Claim 11 (depends on 10)

The method of claim 10, wherein the stent substrate is a bioabsorbable polymer.

### Claim 12 (depends on 10)

The method of claim 10, wherein the polymer component is a bioabsorbable polymer.

### Claim 13 (depends on 10)

The method of claim 10, wherein the thermal treatment comprises blowing a heated gas on the stent.

### Claim 14 (depends on 10)

The method of claim 10, wherein the stent is not baked after the final repetition of the thermal treatment.

### Claim 15 (depends on 10)

The method of claim 10, wherein no additional thermal treatment of the stent is performed after the final repetition of the thermal treatment.

### Claim 16 (depends on 10)

The method of claim 10, wherein the thermal treatment comprises exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component.

### Claim 17 (depends on 10)

The method of claim 10, wherein no additional thermal treatment involving exposure of the stent to a temperature greater than 40° C. is performed or no additional thermal treatment involving exposure for greater than 60 s is performed on the stent.

### Claim 18

A method of coating a stent, comprising:
depositing a composition onto a stent substrate, the composition including a polymer component and a solvent, wherein the composition is uniformly deposited to surfaces of the stent substrate;
blowing a heated gas onto the deposited composition, wherein the heated gas removes solvent from the deposited composition; and
repeating the applying and the blowing one or more times to form a coating comprising less than 2 wt % solvent.

### Claim 19 (depends on 18)

The method of claim 18, wherein the heated gas is nitrogen to create an inert blanket.

### Claim 20 (depends on 18)

The method of claim 18, wherein the heated gas heats the polymer component to a temperature equal to or greater than the Tg of the polymer component.

### Claim 21 (depends on 20)

The method of claim 20, wherein the Tg of the polymer component is greater than room temperature.

### Claim 22 (depends on 20)

The method of claim 20, wherein the Tg of the polymer component is greater than human body temperature.

### Claim 25 (depends on 18)

The method of claim 18, wherein the stent substrate is a bioabsorbable polymer.

### Claim 26 (depends on 18)

The method of claim 18, wherein the polymer component is a bioabsorbable polymer.

### Claim 27 (depends on 18)

The method of claim 18, wherein the stent substrate is poly(L-lactide (PLLA) and the polymer component is poly(DL-lactide) (PDLA), the composition and the coating further comprising a therapeutic agent.