# US 2014/0154332 A1 · Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis

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- Number: US 2014/0154332 A1
- Document ID: US20140154332A1
- Status: Published application
- Kind: A1
- Application number: 14/234,622
- Filed: 2012-07-27
- Published: 2014-06-05
- Earliest claimed: 2011-07-27
- Assignees: Sinoveda Canada, Inc.
- Inventors: Yun Kau Tam
- Web page: https://patentgrep.com/patent/US20140154332A1

## CPC

- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A23L 2/02: containing fruit or vegetable juices
- A23L 33/15: Vitamins
- A23L 33/155: Vitamins A or D
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/165: Complexes or chelates
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 9/20: Pills, tablets, {discs, rods (A61K9/0004, A61K9/0007, A61K9/0056, A61K9/0065 take precedence; for reconstitution of a drink A61K9/0095)}
- A61K 9/2095: {Tabletting processes}
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/593: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A61K 33/30: Zinc; Compounds thereof
- A61K 35/02: from inanimate materials (carbon A61K33/44)
- A61K 35/60: Fish, e.g. seahorses; Fish eggs
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 19/08: for bone diseases, e.g. rachitism, Paget's disease
- A61P 19/10: for osteoporosis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention provides methods of producing dosage forms for formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D3. The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.

## Claims

### Claim 1

A method of preparing tablets comprising calcium acetate, magnesium acetate, zinc acetate and vitamin D3, the method comprises the steps of:
(i) blending a first calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate with a composition comprising vitamin D3; and
(ii) blending the composition obtained from (i) with a second calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate;
(iii) performing one or more rounds of blending wherein in each blending a composition obtained from a previous step is blended with yet another calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate, thereby obtaining composition comprising calcium acetate, magnesium acetate, zinc acetate and vitamin D3 for preparing tablets.

### Claim 2 (depends on 1)

A tablet produced by the method of claim 1.

### Claim 3

A method of preparing soft gel capsules comprising calcium acetate, magnesium acetate, zinc acetate, oil and vitamin D3, the method comprises the steps of:
(i) dissolving vitamin D3 in oil comprising omega 3 or omega 3-6-9; and
(ii) blending the composition obtained from (i) with a calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate, thereby obtaining composition comprising calcium acetate, magnesium acetate, zinc acetate, oil and vitamin D3 for preparing soft gel capsules.

### Claim 4 (depends on 1, 3)

The method of claim 1 or 3, wherein the calcium composition comprises at least 10 percent by weight of calcium acetate, at least 5 percent by weight of magnesium acetate, and at least 0.2 percent by weight of zinc acetate.

### Claim 5 (depends on 3)

The method of claim 3, wherein the oil is fish oil or flaxseed oil.

### Claim 6 (depends on 3)

The method of claim 3, wherein the oil to calcium acetate blend ratio is selected from the group consisting of 1:1, 1.5:1 and 2:1.

### Claim 7 (depends on 3)

The method of claim 3, wherein the oil to calcium ratio is selected from the group consisting of 1:0.14, 1.5:1 and 2:1.

### Claim 8 (depends on 3)

The method of claim 3, wherein the oil to magnesium ratio is selected from the group consisting of 1:0.07, 1.5:0.07 and 2:0.07.

### Claim 9 (depends on 3)

The method of claim 3, wherein the oil to zinc ratio is selected from the group consisting of 1:0.007, 1.5:0.007 and 2:0.007.

### Claim 10 (depends on 3)

A soft gel capsule produced using the method of claim 3.