US 2014/0154330 A1Published application

Spherical particles of clopidogrel bisulfate, pharmaceutical composition comprising the same, and preparation method thereof

AssigneesAstech, Inc., Samjin Pharmaceutical Co., Ltd.

InventorsEui Hwan Cho, Hee Jong Shin, Woo Heon Song, Sun Hwan Lee, Jong Bae Yoon, Jong Sung Park

Life of this patent

Estimating the term…

Loading patent…

Abstract

Disclosed are spherical particles of clopidogrel bisulfate and a pharmaceutical composition containing the same. The spherical particles can be used for preparing a tablet having sufficient hardness through direct compression, by improving unformulable properties of clopidogrel bisulfate such as compressibility, flowability and strong surface electrostatic charges, reduce a problem in compressing tablets such as weight variation, sticking, etc., and the risk of form conversion, and improve physiochemical stability. Therefore, the spherical particles of the present invention may be used as therapeutics for arteriosclerosis, stroke, myocardial infarction and atherosclerosis.

Claims6

Dependent claims

Spherical particles of clopidogrel bisulfate having a particle size (d0.1) of 30 μm or more and a particle size (d0.5) of 50 to 200 μm.

Dependencies are inferred from the claim text.

Facts

Application: 14/131,907Filed 27 Oct 2011
Priority: KR 10-2011-006903912 Jul 2011
Published: 5 Jun 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 9/14
Medicinal preparations characterised by special physical form: particulate form, e.g. powders, Processes for size reducing of pure drugs or the…
A61K 9/20
Medicinal preparations characterised by special physical form: pills, tablets, discs, rods
A61K 9/2018
Organic compounds, e.g. phospholipids, fats: sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2054
Polysaccharides, e.g. alginate, gums; Cyclodextrin: cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose