# US 2014/0154325 A1 · In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles

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- Number: US 2014/0154325 A1
- Document ID: US20140154325A1
- Status: Published application
- Kind: A1
- Application number: 14/175,600
- Filed: 2014-02-07
- Published: 2014-06-05
- Earliest claimed: 2009-01-23
- Assignees: The Penn State Research Foundation
- Applicants: The Penn State Research Foundation
- Inventors: James H. Adair; Mark Kester; Peter C. Eklund; Erhan I. Altinoglu; Brian M. Barth; Timothy J. Russin; James M.D. Kaiser; Thomas T. Morgan
- Web page: https://patentgrep.com/patent/US20140154325A1

## CPC

- A61K 41/0057: {Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent}
- A61K 9/51: Nanocapsules; {Nanoparticles; (nanotubes A61K9/0092; polymeric micelles A61K9/1075; polymersomes A61K9/1273; pure drug nanoparticles A61K9/14; drug nanoparticles with adsorbed surface modifiers A61K9/141; conjugates, e.g. between drug and non-active nanoparticles, A61K47/50; preparations for in vivo diagnosis A61K49/00; with radioactive substances A61K51/00)}
- A61K 47/6921: {the form being a particulate, a powder, an adsorbate, a bead or a sphere}
- A61K 47/6923: {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb}
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 35/04: specific for metastasis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.

## Claims

### Claim 1

A composition comprising a calcium phosphate nanoparticle (CPNP) comprising:
a near-infrared photosensitizer (PS), wherein the nano-encapsulated near-infrared PS has an increased quantum yield as compared to the quantum yield of a control wherein the photosensitizer is not nano-encapsulated,
wherein the CPNP is non-toxic to humans,
wherein the CPNP is biocompatible,
wherein the CPNP is colloidally stable,
wherein the CPNP has a diameter of less than about 100 nm,
wherein the CPNP is non-agglomerating in a physiological fluid,
wherein the nano-encapsulated near-infrared PS has an increased half as compared to the half life of a control, wherein the PS is not nano-encapsulated, and
wherein the CPNP prevents dimerization of the PS.