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AssigneeFolia Biotech Inc.
InventorsDenis Leclerc, Alain Lamarre
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The use of compositions comprising a papaya mosaic virus (PapMV) moiety for stimulation of the innate immune response is provided. The PapMV moiety may be papaya mosaic virus or PapMV virus-like particles (VLPs). The PapMV compositions stimulate a sufficiently strong innate immune response to provide protection against subsequent pathogen challenge or to treat an established infection. The use of PapMV compositions to protect a subject from potential infection by a pathogen, such as a viral pathogen, a bacterial pathogen or a fungal pathogen, and the use of PapMV compositions to treat an established infection, are also provided. The PapMV compositions be administered, for example, via intranasal or pulmonary routes to elicit effects within the mucosa and/or in the respiratory system.
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A method of stimulating an innate immune response in a subject comprising administering to the subject an effective amount of a composition comprising papaya mosaic virus (PapMV) or PapMV virus-like particles (VLPs), thereby preventing, or decreasing the severity of, a microbial infection in the subject.
A method of protecting a subject against infection with a pathogen comprising administering to the subject an effective amount of a composition comprising papaya mosaic virus (PapMV) or PapMV virus-like particles (VLPs), wherein the composition stimulates the innate immune response in the subject.
A method of treating a chronic or recurrent microbial infection comprising administering to a subject having a chronic or recurrent microbial infection a composition comprising Papaya Mosaic Virus (PapMV) or PapMV virus-like particles (VLPs).
A kit comprising a container having contained therein a pharmaceutical composition comprising papaya mosaic virus (PapMV) or PapMV virus-like particles (VLPs), the container adapted to deliver the pharmaceutical composition by an intranasal, pulmonary or vaginal route.
Dependencies are inferred from the claim text.