# US 2014/0153690 A1 · Systems and methods for imaging dynamic processes > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0153690 A1 - Document ID: US20140153690A1 - Status: Published application - Kind: A1 - Application number: 14/090,677 - Filed: 2013-11-26 - Published: 2014-06-05 - Earliest claimed: 2012-11-30 - Assignees: General Electric Company - Applicants: General Electric Company - Inventors: Bernhard Erich Hermann CLAUS; Jeffrey Wayne EBERHARD; David Allen LANGAN; Kedar Bhalchandra KHARE - Web page: https://patentgrep.com/patent/US20140153690A1 ## CPC - A61B 6/025: {Tomosynthesis} - A61B 6/027: {characterised by the use of a particular data acquisition trajectory, e.g. helical or spiral} - A61B 6/4441: {the rigid structure being a C-arm or U-arm} - A61B 6/542: {involving control of exposure} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Systems, methods and non-transitory computer readable media for imaging. The system includes one or more radiation sources and detectors configured to transmit x-ray radiation towards a subject for imaging a dynamic process in a ROI of the subject and to acquire projection data corresponding to the ROI, respectively. The system also includes a computing device operatively coupled to one or more of the radiation sources and the detectors. The computing device is configured to provide control signals for performing one or more reference scans for acquiring reference data from a plurality of angular positions around the subject and for performing one or more tomosynthesis scans using one or more tomosynthesis trajectories for acquiring tomosynthesis data following the onset of the dynamic process. Additionally, the computing device is configured to reconstruct one or more images representative of the dynamic process using the reference data and/or the tomosynthesis data. ## Claims ### Claim 1 An imaging system, comprising: one or more radiation sources configured to transmit x-ray radiation towards a subject for imaging a dynamic process in a region of interest of the subject; one or more detectors configured to acquire projection data corresponding to the region of interest; and a computing device operatively coupled to one or more of the radiation sources and to the detectors, wherein the computing device is configured to: provide control signals for performing one or more reference scans for acquiring reference data from a plurality of angular positions around the subject; provide control signals for performing one or more tomosynthesis scans using one or more tomosynthesis trajectories for acquiring tomosynthesis data following onset of the dynamic process; and reconstruct one or more images representative of the dynamic process using the reference data, the tomosynthesis data, or a combination thereof ### Claim 2 (depends on 1) The system of claim 1, wherein the onset of the dynamic process corresponds to an administration of a contrast agent to the subject and/or a commencement of a motion of an interventional device. ### Claim 3 (depends on 1) The system of claim 1, wherein the one or more reference scans comprise a spin scan, a tomosynthesis scan, or a combination thereof. ### Claim 4 (depends on 1) The system of claim 1, wherein at least one of the one or more reference scans comprises a part of a continuous tomosynthesis scan performed before the onset of the dynamic process. ### Claim 5 (depends on 1) The system of claim 1, wherein the reference scan comprises an augmented tomosynthesis scan, wherein the augmented tomosynthesis scan uses additional views, denser sampling along a reference scan trajectory, a scanning trajectory having a determined tomographic angle, a spin trajectory, or combinations thereof. ### Claim 6 (depends on 1) The system of claim 1, wherein the one or more images representative of the dynamic process are generated from two or more three-dimensional volumes. ### Claim 7 (depends on 1) The system of claim 1, wherein the computing device is configured to reconstruct the one or more images based on a determined difference between the reference data and the tomosynthesis data in a projection domain. ### Claim 8 (depends on 1) The system of claim 1, wherein projection data representative of the reference scan is obtained by re-projecting a three-dimensional volume reconstructed from the reference data acquired during at least one of the reference scans. ### Claim 9 (depends on 1) The system of claim 1, wherein projection data representative of the reference scan is generated directly from the reference data acquired during at least one of the reference scans. ### Claim 10 (depends on 1) The system of claim 1, wherein the one or more tomosynthesis trajectories comprise a closed acquisition trajectory, an open acquisition trajectory, or a combination thereof. ### Claim 11 An imaging method, comprising: performing one or more reference scans for acquiring reference data from a plurality of angular positions around a subject; allowing for onset of a dynamic process in a region of interest of the subject; performing one or more tomosynthesis scans using one or more tomosynthesis trajectories for acquiring tomosynthesis data; and reconstructing one or more images representative of the dynamic process using the reference data, the tomosynthesis data, or a combination thereof ### Claim 12 (depends on 11) The method of claim 11, wherein allowing for the onset of the dynamic process comprises administration of a contrast agent to the subject and/or commencement of a motion of an interventional device. ### Claim 13 (depends on 11) The method of claim 11, wherein the one or more reference scans comprise an augmented tomosynthesis scan, wherein the augmented tomosynthesis scan uses additional views, denser sampling along a reference scan trajectory, a scanning trajectory having a determined tomographic angle, a spin trajectory, or combinations thereof. ### Claim 14 (depends on 11) The method of claim 11, wherein at least one of the one or more reference scans comprise a part of a continuous tomosynthesis scan performed before onset of the dynamic process. ### Claim 15 (depends on 11) The method of claim 11, wherein reconstructing the one or more images representative of the dynamic process are generated from two or more three-dimensional volumes corresponding to the region of interest of the subject. ### Claim 16 (depends on 11) The method of claim 11, wherein reconstructing the one or more images comprises: determining a difference between the reference data and the tomosynthesis data in the projection domain; and reconstructing the one or more images based on the determined difference. ### Claim 17 (depends on 11) The method of claim 11, further comprising obtaining projection data representative of the reference scan by re-projecting a three-dimensional volume reconstructed from the reference data acquired during at least one of the reference scans. ### Claim 18 (depends on 11) The system of claim 11, further comprising generating projection data representative of the reference scan directly from the reference data acquired during at least one of the reference scans. ### Claim 19 (depends on 11) The method of claim 11, wherein reconstructing the one or more images representative of the dynamic process comprises using a sparsity-constrained image reconstruction technique. ### Claim 20 (depends on 11) The method of claim 11, further comprising performing functional analysis of the region of interest, guiding an interventional device, studying one or more perfusion parameters, or combinations thereof, based on the one or more images representative of the dynamic process. ### Claim 21 A non-transitory computer readable medium that stores instructions executable by one or more processors to perform a method for imaging, comprising: performing one or more reference scans for acquiring reference data from a plurality of angular positions around a subject; allowing for onset of a dynamic process in a region of interest of the subject; performing one or more tomosynthesis scans using one or more tomosynthesis trajectories for acquiring tomosynthesis data; and reconstructing one or more images representative of the dynamic process using the reference data, the tomosynthesis data, or a combination thereof