# US 2014/0153356 A1 · Cassette system integrated apparatus

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- Number: US 2014/0153356 A1
- Document ID: US20140153356A1
- Status: Published application
- Kind: A1
- Application number: 13/914,138
- Filed: 2013-06-10
- Published: 2014-06-05
- Earliest claimed: 2007-02-27
- Assignees: DEKA Products Limited Partnership
- Inventors: Kevin L. Giant; James D. Dale; Jason A. Demers; Michael J. Wilt
- Web page: https://patentgrep.com/patent/US20140153356A1

## CPC

- A61M 1/1639: {linked by membranes}
- F04B 43/026: {each plate-like pumping flexible member working in its own pumping chamber}
- A61M 1/154: {with sensing means or components thereof}
- A61M 1/155: {with treatment-fluid pumping means or components thereof}
- A61M 1/1561: {at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil}
- A61M 1/15625: {the reservoirs acting as balance chambers}
- A61M 1/1565: {Details of valves}
- A61M 1/16: with membranes
- A61M 1/1605: {Physical characteristics of the dialysate fluid}
- A61M 1/1664: {with temperature control}
- A61M 1/1666: {by dissolving solids}
- A61M 1/287: {Dialysates therefor}
- A61M 60/113: in other functional devices, e.g. dialysers or heart-lung machines
- A61M 60/268: the displacement member being flexible, e.g. membranes, diaphragms or bladders
- A61M 60/37: Haemodialysis, haemofiltration or diafiltration
- A61M 60/427: the force acting on the blood contacting member being hydraulic or pneumatic
- A61M 60/837: Aspects of flexible displacement members, e.g. shapes or materials
- A61M 60/847: arranged in a cassette
- A61M 60/849: Disposable parts
- A61M 60/851: Valves
- F04B 7/02: the valving being fluid-actuated
- F04B 43/06: Pumps having fluid drive
- F04B 43/0736: {with two or more pumping chambers in parallel}
- F04B 45/0536: {the actuating fluid being controlled by one or more valves}
- A61M 60/43: using vacuum at the blood pump, e.g. to accelerate filling
- A61M 60/892: Active valves, i.e. actuated by an external force
- A61M 60/894: Passive valves, i.e. valves actuated by the blood
- A61M 2205/12: with interchangeable cassettes forming partially or totally the fluid circuit
- A61M 2205/3317: Electromagnetic, inductive or dielectric measuring means
- A61M 2205/3324: PH measuring means
- A61M 2205/3368: Temperature
- Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
- Y10T 137/0324: With control of flow by a condition or characteristic of a fluid
- Y10T 137/0379: By fluid pressure
- Y10T 137/2521: Flow comparison or differential response
- Y10T 137/85978: With pump
- Y10T 137/86139: Serial
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- F04B: POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS (machines for liquids, or pumps, of rotary-piston or oscillating-piston type F04C; non-positive-displacement pumps F04D; pumping of fluid by direct contact of another fluid or by using inertia of fluid to be pumped F04F)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

## Claims

### Claim at position 1

1-20. (canceled)

### Claim 21

An integrated cassette system comprising a fluid mixing cassette, a middle cassette and a fluid balancing cassette, the middle cassette interposed between the mixing cassette and the balancing cassette;
the integrated cassette system comprising:
a mixing chamber interposed between and fluidly connected to the mixing cassette and the middle cassette, the mixing chamber having a first fluid port connected to the mixing cassette and a second fluid port connected to the middle cassette;
a mixing cassette reciprocating membrane pump interposed between and fluidly connected to the mixing cassette and the middle cassette, the mixing cassette reciprocating membrane pump configured to pump fluid to the mixing chamber;
a balancing chamber interposed between the middle cassette and the balancing cassette, the balancing chamber comprising a flexible membrane separating the balancing chamber into a first fluid compartment and a second fluid compartment, the first fluid compartment in fluid communication with the middle cassette and the second fluid compartment in fluid communication with the fluid balancing cassette;
a balancing cassette reciprocating membrane pump interposed between and fluidly connected to the middle cassette and the balancing cassette, the balancing cassette reciprocating membrane pump configured to pump fluid into the first fluid compartment of the balancing chamber, displacing an equal volume of fluid from the second fluid compartment of the balancing chamber, or configured to pump fluid into the second fluid compartment of the balancing chamber, displacing an equal volume of fluid from the first fluid compartment of the balancing chamber;
the mixing cassette comprising:
a first mixing cassette inlet fluidly connected to the mixing cassette reciprocating membrane pump, the mixing cassette reciprocating membrane pump having a pumping chamber configured to receive a first fluid and to deliver a pre-determined volume of fluid from the pumping chamber to the mixing chamber;
a second mixing cassette fluid inlet fluidly connected to a mixing cassette metering pump on the mixing cassette, the mixing cassette metering pump configured to receive a second fluid and to pump a pre-determined volume of the second fluid into the mixing chamber;
the balancing cassette comprising:
a balancing cassette fluid inlet fluidly connected to the balancing cassette reciprocating membrane pump; and
a balancing cassette metering pump fluidly connected to the balancing cassette fluid inlet, the balancing cassette metering pump configured to pump fluid from the balancing cassette fluid inlet to bypass the balancing cassette reciprocating membrane pump.

### Claim 22 (depends on 21)

The integrated cassette system of claim 21, wherein the mixing cassette is fluidly connected to the middle cassette by a rigid fluid-carrying conduit and the middle cassette is fluidly connected to the balancing cassette by a second rigid fluid-carrying conduit.

### Claim 23 (depends on 21)

The integrated cassette system of claim 21, further comprising:
a second balancing chamber interposed between the middle cassette and the balancing cassette, the second balancing chamber comprising a flexible membrane separating the second balancing chamber into a first fluid compartment and a second fluid compartment, the first fluid compartment in fluid communication with the middle cassette and the second fluid compartment in fluid communication with the fluid balancing cassette; and
a second balancing cassette reciprocating membrane pump interposed between and fluidly connected to the middle cassette and the balancing cassette, the second balancing cassette reciprocating membrane pump configured to pump fluid into the first fluid compartment of the second balancing chamber, displacing an equal volume of fluid from the second fluid compartment of the second balancing chamber, or configured to pump fluid into the second fluid compartment of the second balancing chamber, displacing an equal volume of fluid from the first fluid compartment of the second balancing chamber.

### Claim 24 (depends on 21)

The integrated cassette system of claim 21, wherein a first balancing fluid inlet is fluidly connected to the balancing cassette reciprocating membrane pump;
wherein a second balancing fluid inlet is fluidly connected to the first fluid compartment if the balancing cassette reciprocating membrane pump is fluidly connected to the second fluid compartment, or the second balancing fluid inlet is fluidly connected to the second fluid compartment if the balancing cassette reciprocating membrane pump is fluidly connected to the first fluid compartment; and
wherein the balancing cassette reciprocating membrane pump is configured to pump a first fluid from the first balancing fluid inlet to a fluid compartment of the balancing chamber to which said pump is connected to displace an equal volume of second fluid present in a fluid compartment of the balancing chamber to which the second balancing fluid inlet is connected.

### Claim 25 (depends on 24)

The integrated cassette system of claim 24, wherein the first balancing fluid inlet is configured for connection to a dialysate outlet of a dialyzer in a dialysis system, and the second balancing fluid inlet is configured for connection to a source of clean dialysate, and wherein the fluid compartment connected to the second balancing fluid inlet is fluidly connected to an outlet of the integrated cassette system, the outlet configured for connection to a dialysate inlet of a dialyzer in the dialysis system.

### Claim 26 (depends on 25)

The integrated cassette system of claim 25, wherein the balancing cassette metering pump is configured to pump used dialysate from the dialysate outlet of the dialyzer, bypassing the balancing cassette reciprocating membrane pump and balancing chamber.

### Claim 27 (depends on 21)

The integrated cassette system of claim 21, further comprising a third mixing cassette fluid inlet fluidly connected to a second mixing cassette metering pump on the mixing cassette, the second mixing cassette metering pump configured receive a third fluid and to pump the third fluid into the pumping chamber of the mixing cassette reciprocating membrane pump, wherein a pre-determined volume of first and pre-determined volume of third fluid may be mixed in the mixing cassette reciprocating membrane pump for delivery to the mixing chamber.

### Claim 28 (depends on 27)

The integrated cassette system of claim 27, wherein the second mixing cassette fluid inlet is configured to connect to an acid solution source for dialysate preparation, and the third cassette fluid inlet is configured to connect to a bicarbonate solution source for dialysate preparation.

### Claim 29 (depends on 27)

The integrated cassette system of claim 27, wherein the second mixing cassette fluid inlet is configured to connect to a bicarbonate solution source for dialysate preparation, and the third cassette fluid inlet is configured to connect to an acid solution source for dialysate preparation.

### Claim 30 (depends on 21)

The integrated cassette system of claim 21, wherein a stroke volume of the balancing chamber reciprocating membrane pump is approximately equal to a liquid volume of the balancing chamber.

### Claim 31 (depends on 21)

The integrated cassette system of claim 21, wherein a stroke volume of the mixing chamber reciprocating membrane pump is approximately equal to a liquid volume of the mixing chamber.

### Claim 32 (depends on 21)

The integrated cassette system of claim 21, wherein the balancing cassette metering pump comprises a reciprocating membrane pump.

### Claim 33 (depends on 32)

The integrated cassette system of claim 32, wherein a stroke volume of the balancing cassette metering pump is smaller than a stroke volume of the balancing cassette reciprocating membrane pump.

### Claim 34 (depends on 21)

The integrated cassette system of claim 21, wherein the mixing cassette metering pump comprises a reciprocating membrane pump.

### Claim 35 (depends on 34)

The integrated cassette system of claim 34, wherein a stroke volume of the mixing cassette metering pump is smaller than a stroke volume of the mixing cassette reciprocating membrane pump.