# US 2014/0151546 A1 · Multi-capillary column and high-capacity ionization interface for gc-ms

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- Number: US 2014/0151546 A1
- Document ID: US20140151546A1
- Status: Published application
- Kind: A1
- Application number: 14/054,703
- Filed: 2013-10-15
- Published: 2014-06-05
- Earliest claimed: 2012-11-30
- Assignees: Agilent Technologies, Inc.
- Applicants: Agilent Technologies, Inc.
- Inventors: Gangqiang Li; Maozi Liu
- Web page: https://patentgrep.com/patent/US20140151546A1

## CPC

- G01N 30/7206: {interfaced to gas chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04)}
- H01J 49/062: {Ion guides (linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421)}
- G01N 30/466: {with separation columns in parallel}
- G01N 30/467: {all columns being identical}
- G01N 30/6043: {in parallel}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H)

## Abstract

A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging.

## Claims

### Claim 1

A gas chromatograph-mass spectrometer (GC-MS) system, comprising:
a column comprising a column outlet and a plurality of capillaries arranged for establishing respective, simultaneous gas flows to the column outlet;
an ionization interface communicating with the column outlet and comprising an ionization device and an ion guide, the ion guide comprising a guide entrance, a guide exit and a plurality of guide electrodes arranged around a guide axis and between the guide entrance and the guide exit, wherein the guide electrodes are configured for constraining ions to an ion beam that radially converges toward the guide exit; and
a mass analyzer communicating with the guide exit.

### Claim 2 (depends on 1)

The GC-MS system of claim 1, wherein each capillary has an inside diameter ranging from 20 μm to 200 μm.

### Claim 3 (depends on 1)

The GC-MS system of claim 1, wherein the ionization device is configured for operating at a pressure ranging from 100 Torr to 0.01 Torr.

### Claim 4 (depends on 1)

The GC-MS system of claim 1, comprising a vacuum system configured for maintaining the ionization interface at a pressure ranging from 100 Torr to 0.01 Torr.

### Claim 5 (depends on 1)

The GC-MS system of claim 1, wherein the ionization device is selected from the group consisting of a photo-ionization device, a chemical ionization device, a field ionization device, a glow discharge device, and a corona discharge device.

### Claim 6 (depends on 1)

The GC-MS system of claim 1, wherein the ionization device is positioned upstream of the ion guide, or inside the ion guide.

### Claim 7 (depends on 1)

The GC-MS system of claim 1, wherein the ion guide comprises a first ion guide and a second ion guide disposed between the first ion guide and the mass analyzer.

### Claim 8 (depends on 7)

The GC-MS system of claim 7, comprising a vacuum system configured for maintaining the second ion guide at a lower pressure than the first ion guide.

### Claim 9 (depends on 1)

The GC-MS system of claim 1, wherein the guide exit has an inside diameter ranging from 50 to 97% smaller than an inside diameter of the guide entrance.

### Claim 10

A method for acquiring a mass spectrum from a sample gas, the method comprising:
flowing the sample gas simultaneously through a plurality of capillaries of a gas chromatograph and into an ionization interface;
ionizing the sample gas in the ionization interface to produce ions;
transmitting the ions through an ion guide and into a mass analyzer;
while transmitting the ions, confining the ions to an ion beam that radially converges along an axial length of the ion guide; and
while ionizing and transmitting the ions, maintaining the ionization interface at an intermediate pressure between a pressure in the gas chromatograph and a pressure in the mass analyzer.

### Claim 11 (depends on 10)

The method of claim 10, wherein the sample gas is flowed through the capillaries at a total flow rate ranging from 1 mL/min to 2000 mL/min.

### Claim 12 (depends on 10)

The method of claim 10, wherein the intermediate pressure ranges from 100 Torr to 0.01 Torr.

### Claim 13 (depends on 10)

The method of claim 10, wherein ionizing comprises operating an ionization device upstream of the ion guide.

### Claim 14 (depends on 10)

The method of claim 10, comprising flowing the sample gas into the ion guide, wherein ionizing is performed in the ion guide.

### Claim 15 (depends on 10)

The method of claim 10, wherein transmitting the ions into the mass analyzer comprises operating the ion guide to accelerate the ions.

### Claim 16 (depends on 10)

The method of claim 10, comprising, while confining the ions, reducing the kinetic energy of the ions.

### Claim 17 (depends on 16)

The method of claim 16, wherein reducing comprises flowing a damping gas into the ionization interface.

### Claim 18 (depends on 10)

The method of claim 10, wherein the ion guide comprises a first ion guide and a second ion guide, and transmitting the ions comprises transmitting the ions as a converged beam through the first ion guide at a first intermediate pressure, and transmitting the ions as a converged beam through the second ion guide at a second intermediate pressure lower than the first intermediate pressure.

### Claim 19 (depends on 18)

The method of claim 18, wherein the first intermediate pressure ranges from 100 to 5 Torr, and the second intermediate pressure ranges from 5 to 0.01 Torr.

### Claim 20 (depends on 10)

A gas chromatograph-mass spectrometer system configured for performing the method of claim 10.