# US 2014/0151244 A1 · Systems and methods of discriminating between a control sample and a test fluid using capacitance

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- Number: US 2014/0151244 A1
- Document ID: US20140151244A1
- Status: Published application
- Kind: A1
- Application number: 14/087,473
- Filed: 2013-11-22
- Published: 2014-06-05
- Earliest claimed: 2010-09-30
- Assignees: Cilag GmbH International
- Applicants: Cilag GmbH International
- Inventors: Ronald C. Chatelier; Alastair M. Hodges
- Web page: https://patentgrep.com/patent/US20140151244A1

## CPC

- G01N 27/28: Electrolytic cell components
- C12Q 1/005: {involving specific analytes or enzymes (including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence)}
- G01N 27/3274: {Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771)}
- G01N 33/48707: {by electrical means (G01N33/49, G01N33/493 take precedence)}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample are provided herein. In one aspect, the method includes using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non-blood sample based on characteristics of the sample (e.g., amount of interferent present, reaction kinetics, and/or capacitance). The method can also include calculating a discrimination criteria based upon these characteristics. Various aspects of a system for distinguishing between a blood sample and an aqueous non-blood sample are also provided herein.

## Claims

### Claim 1

A method for calculating a discrimination criteria for programming into a test meter for distinguishing between a blood sample and an aqueous non-blood sample, the method comprising:
(a) calculating a first reference value and a second reference value for a plurality of aqueous non-blood samples,
(b) calculating a third reference value based on the first reference value, the third reference value being proportional to a capacitance index; and
(b) calculating a discrimination criteria based on the second reference value and the third reference value for the plurality of aqueous non-blood samples.

### Claim 2 (depends on 1)

The method of claim 1, wherein the first reference value is representative of antioxidant concentration and the second reference value is representative of reaction kinetics.

### Claim 3 (depends on 1)

The method of claim 1, wherein the capacitance index comprises a ratio of an average capacitance of electrochemical cells of the same type and the measured capacitance of the electrochemical cell when a sample is introduced.

### Claim 4 (depends on 1)

The method of claim 1, wherein the plurality of aqueous non-blood samples comprise a plurality of control solutions.