# US 2014/0150923 A1 · Arrangement and method for injecting a fluid into an analysis appliance > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2014/0150923 A1 - Document ID: US20140150923A1 - Status: Published application - Kind: A1 - Application number: 14/096,830 - Filed: 2013-12-04 - Published: 2014-06-05 - Earliest claimed: 2012-12-05 - Assignees: CTC Analytics AG - Applicants: Ctc Analytics AG - Inventors: Peter STALDER; Lucas LUETHY - Web page: https://patentgrep.com/patent/US20140150923A1 ## CPC - G01N 30/18: using a septum or microsyringe - G01N 30/24: Automatic injection systems - G01N 2030/185: {specially adapted to seal the inlet} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Arrangement and method for injecting a fluid into an analysis appliance, in particular into a liquid chromatograph with an injection opening. The arrangement includes a manipulating device with an injection needle, and a seal, in particular a ferrule, which is made of a polymer material and is arranged removably on the injection opening. In the axial direction, the seal has a guide bore for receiving the injection needle. The guide bore includes a shoulder with an opening, of which the diameter is smaller than a diameter in a first portion of the guide bore extending from the shoulder in the direction of a first end of the seal. The injection needle can be inserted into the guide bore from the direction of the first end of the seal, and the front edge of the injection needle can be pressed onto the shoulder with a predetermined force. ## Claims ### Claim at position 1 1-14. (canceled) ### Claim 15 Arrangement for injecting a fluid into an analysis appliance, in particular into a liquid chromatograph, comprising a manipulating device with an injection needle and a seal made of a polymer material, said seal being removably arranged on an injection opening of the analysis appliance and having a guide bore in an axial direction for receiving the injection needle, wherein the guide bore comprises a shoulder with an opening with a diameter smaller than a diameter in a first portion of the guide bore, said first portion extending from the shoulder in the direction of a first end of the seal, and wherein the manipulating device has means for inserting the injection needle into the guide bore from the direction of the first end of the seal and for pressing a front edge of the injection needle onto the shoulder with a predetermined and constant force. ### Claim 16 (depends on 15) Arrangement according to claim 15, wherein the seal is made of polyetheretherketone. ### Claim 17 (depends on 15) Arrangement according to claim 15, wherein the first portion of the guide bore has a constant diameter which corresponds to an external diameter of the injection needle. ### Claim 18 (depends on 15) Arrangement according to claim 15, wherein said guide bore comprises a second portion which extends from the shoulder to the second end of the seal, said second end bearing on the injection opening when said seal is arranged on said injection opening, said second portion having a diameter which is smaller than the diameter of the guide bore in the first portion. ### Claim 19 (depends on 15) Arrangement according to claim 15, wherein the diameter of the guide bore in the first portion is from 0.2 mm to 2.0 mm. ### Claim 20 (depends on 15) Arrangement according to claim 15, wherein the means of the manipulating device are configured such that the injection needle is pressed onto the shoulder with a predetermined force of 1 N to 50 N. ### Claim 21 (depends on 15) Arrangement according to claim 15, wherein the means of the manipulating device is a drive with which the injection needle is movable in a first spatial direction which is parallel to the guide bore. ### Claim 22 (depends on 21) Arrangement according to claim 21, wherein the manipulating device is driveable in at least one further spatial direction, which is orthogonal to the first spatial direction. ### Claim 23 Method for injecting a fluid into an analysis appliance with an injection opening, said method comprising the steps of: a) arranging a seal with an axial guide bore on the injection opening, wherein the guide bore comprises a first portion with a first diameter and a shoulder with an opening having a second diameter which is smaller than said first diameter; b) inserting an injection needle with an external diameter corresponding to the first diameter of the guide bore into the first portion of the guide bore until a front end of the injection needle abuts on said shoulder; c) pressing the injection needle onto said shoulder with a predetermined and constant force; d) injecting the fluid into the injection opening. ### Claim 24 (depends on 23) Method according to claim 23, wherein the injection needle is pressed onto the shoulder with a predetermined force of 1 N to 50 N. ### Claim 25 (depends on 23) Method according to claim 23, wherein the seal is releasably arranged on the injection opening by application of a holder and is pressed by this holder onto an area of the analysis appliance surrounding the injection opening. ### Claim 26 (depends on 15) Analysis appliance with an injection opening for a fluid with at least one arrangement according to claim 15. ### Claim 27 (depends on 26) Analysis appliance according to claim 26, wherein the analysis appliance has a recess in the area of the injection opening into which recess the seal is fitted in such a way that the guide bore is arranged coaxially with respect to the injection opening. ### Claim 28 (depends on 26) Analysis appliance according to claim 26, wherein the analysis appliance has fastening means for a holder with which the seal is fixed on the injection opening. ### Claim 29 (depends on 18) Arrangement according to claim 18, wherein the diameter of the guide bore in the second portion has the same size as the diameter of the opening. ### Claim 30 (depends on 16) Analysis appliance with an injection opening for a fluid with at least one arrangement according to claim 16. ### Claim 31 (depends on 17) Analysis appliance with an injection opening for a fluid with at least one arrangement according to claim 17. ### Claim 32 (depends on 18) Analysis appliance with an injection opening for a fluid with at least one arrangement according to claim 18. ### Claim 33 (depends on 19) Analysis appliance with an injection opening for a fluid with at least one arrangement according to claim 19. ### Claim 34 (depends on 20) Analysis appliance with an injection opening for a fluid with at least one arrangement according to claim 20.