# US 2014/0150522 A1 · Dispensed Liquid Measurement Device

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- Number: US 2014/0150522 A1
- Document ID: US20140150522A1
- Status: Published application
- Kind: A1
- Application number: 14/096,940
- Filed: 2013-12-04
- Published: 2014-06-05
- Earliest claimed: 2012-12-05
- Inventors: Ian K. Glasgow; Kelly Magin; Brian Kolb; Andrea Habura
- Web page: https://patentgrep.com/patent/US20140150522A1

## CPC

- B01L 3/0293: {for liquids}
- B01L 3/5027: {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip}
- G01F 17/00: Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies (measuring linear dimensions to determine volume G01B)
- G01F 25/0084: {for measuring volume}
- G01F 25/0092: {for metering by volume}
- B01L 2200/148: Specific details about calibrations
- B01L 2300/028: Graduation
- B01L 2300/0838: Capillaries
- B01L 2400/0406: capillary forces
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01F: MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME

## Abstract

A measurement device containing one or more capillaries to measure the volume of a dispensed fluid and determine the volumetric accuracy of the dispensing device. The measurement device can contain a reservoir containing the fluid to be measured and there may be an additional reservoir for a secondary fluid. A viewing window is necessary to complete a manual measurement and may include a magnifying lens. The liquid well by the capillary inlet may be shaped such that the measurement fluid is directed toward the capillary. The well may have features designed to position the dispensing device toward the capillary, or to position the well proximal to the capillary after it is filled. The well may also have surfaces or coatings which attract or do not attract various types of substances. The measurement device may interface with sensors to output measurement data.

## Claims

### Claim 1

A liquid measurement device for verifying the calibration of a pipettor or other fluid dispenser, comprising:
a. a well for receiving liquid from said fluid dispenser;
b. a capillary positioned so that its proximal end is facing said well;
c. said capillary having an opening at its proximal end; and
d. said capillary having a diameter capable of drawing liquid from said well using surface tension when said capillary and said well are positioned close to or in contact with each other.

### Claim 2 (depends on 1)

The liquid measurement device of claim 1, wherein said device has a viewing area at a preselected point along the length of said capillary enabling a user to determine the volume of liquid drawn into said capillary.

### Claim 3 (depends on 2)

The liquid measurement device of claim 2, wherein said device contains a magnifying lens at its viewing area.

### Claim 4 (depends on 2)

The liquid measurement device of claim 2, wherein said capillary contains markings to delineate predetermined volumes of liquid.

### Claim 5 (depends on 1)

The liquid measurement device of claim 1, wherein said device has a means for measuring the volume of liquid drawn into said capillary.

### Claim 6 (depends on 1)

The liquid measurement device of claim 1, wherein said device contains a sensor to indicate whether the volume of liquid drawn into said capillary is within a range of predetermined volumes.

### Claim 7 (depends on 1)

The liquid measurement device of claim 1, wherein said device contains a means for moving said well towards said capillary.

### Claim 8 (depends on 7)

The liquid measurement device of claim 7, wherein said device contains a means for moving said well to be within 0.5 mm of said capillary.

### Claim 9 (depends on 1)

The liquid measurement device of claim 1, wherein said device contains a means for moving said capillary towards said well.

### Claim 10 (depends on 9)

The liquid measurement device of claim 9, wherein said device contains a means for moving said capillary to be within 0.5 mm of said well.

### Claim 11 (depends on 1)

The liquid measurement device of claim 1, wherein said device contains an additional reservoir capable of storing liquid to be measured.

### Claim 12 (depends on 11)

The liquid measurement device of claim 11, wherein said reservoir contains a colored liquid to allow for distinct identification of said liquid to be measured.

### Claim 13 (depends on 1)

The liquid measurement device of claim 1, wherein said capillary is positioned at an incline so that its proximal end that is facing the well is slightly lower than its distal end.

### Claim 14 (depends on 1)

The liquid measurement device of claim 1, wherein said capillary is constructed of a hydrophilic material.

### Claim 15 (depends on 1)

The liquid measurement device of claim 1, wherein said well is constructed of a hydrophobic material.

### Claim 16 (depends on 1)

The liquid measurement device of claim 1, wherein said device contains one or more V-shaped or inverted V-shaped structures to support said fluid dispenser while it is dispensing fluid into said well.

### Claim 17 (depends on 1)

The liquid measurement device of claim 1, wherein said device contains a plurality of said capillaries and a plurality of said wells in a one-to-one correspondence.

### Claim 18 (depends on 17)

The liquid measurement device of claim 17, wherein said device has a housing with multiple channels, each said channel having one capillary and one well and each said channel capable of being separated from an adjacent channel.

### Claim 19 (depends on 17)

The liquid measurement device of claim 17, wherein said device is configured to be compatible with laboratory instrumentation for use with standardized microtiter plates.

### Claim 20 (depends on 1)

The liquid measurement device of claim 1, wherein said device has a module to be placed on the tip of said pipettor or fluid dispenser that will guide, place or lock said pipettor or fluid dispenser in a predetermined location relative to said well

### Claim 21

A liquid measurement device for verifying the calibration of a pipettor or other fluid dispenser, comprising:
a. a well for receiving liquid from said fluid dispenser;
b. a capillary positioned so that its proximal end is facing the well;
c. said capillary having an opening at its proximal end;
d. said capillary having a diameter capable of drawing liquid from said well using surface tension when said capillary and said well are positioned close to or in contact with each other;
e. said capillary containing or being placed near markings to delineate predetermined volumes of liquid; and
f. a viewing area at a preselected point along the length of said capillary.

### Claim 22 (depends on 21)

The liquid measurement device of claim 21, wherein said device contains a means for moving said well or said capillary towards the other.

### Claim 23 (depends on 21)

The liquid measurement device of claim 21, wherein said device contains a plurality of said capillaries and a plurality of said wells in a one-to-one correspondence.
