Methods of improving vaccine immunogenicity
AssigneeUniversity of Iowa Research Foundation
InventorsGail Bishop, Tony Vanden Bush
Life of this patent
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Abstract
The present invention provides a process called “Immune Banking” that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody response. This recognition of the tagged vaccine components enhances adaptive immune responses to the new vaccine.
Claims33
A VP-1 epitope of polio of about 11-28 amino acids in length comprising IPALTAVETGA (SEQ ID NO:
- 1) or ALTAVETGAT (SEQ ID NO:
- 3).
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A method of eliciting an immune response in a pre-immunized animal comprising introducing into the animal the composition comprising a compound comprising at least one antigen covalently bound to an antibody-recognition epitope (ARE), wherein the ARE is a VP-1 epitope of polio of about 11-28 amino acids in length comprising IPALTAVETGA (SEQ ID NO:
- 1) or ALTAVETGAT (SEQ ID NO:
- 3), and a physiologically-acceptable, non-toxic vehicle.
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Dependencies are inferred from the claim text.