Somatic Cells with Innate Potential for Pluripotency
AssigneeThe Regents of the University of California
InventorThea D. Tlsty
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Abstract
Aspects of the present invention are drawn to compositions of somatic cells with innate potential for pluripotency (SCIPP). SCIPP have the capacity to differentiate into functional derivatives of each of the major germ layers (i.e., ectodermal, endodermal and mesodermal). Also provided are methods and kits for identifying and isolating the somatic cells from a subject as well as for employing SCIPP for research or therapeutic purposes.
Claims23
An isolated population of cells wherein at least 8% of the cells are Somatic Cells with an Innate Potential for Pluripotency (SCIPP).
A method for producing a sample enriched for Somatic Cells with an Innate Potential for Pluripotency (SCIPP), the method comprising:
- culturing a cell sample from a subject under conditions that promote the differential maintenance and growth of SCIPP.
A method of screening for factors that affect cell differentiation, the method comprising:
- combining a candidate differentiation factor with a population of cells comprising at least 1% Somatic Cells with an Innate Potential for Pluripotency (SCIPP);
- and
- monitoring the effect of the candidate differentiation factor on the formation of differentiated cells from the SCIPP.
Dependencies are inferred from the claim text.