Stable compositions containing thrombin and methods for preparation and use thereof
AssigneeOrthovita, Inc.
InventorVenkat R. Garigapati
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Abstract
Compositions comprising thrombin and collagen and methods of preparation thereof are disclosed herein. In one embodiment, a composition comprises thrombin and collagen in an aqueous buffer solution, wherein the buffer solution includes at least one of a first compound represented by Formula I: R1—C(O)—O−M+, wherein R1 is —CH3, —CH2CH2C(O)OH, or —CH2CH2C(O)O−M+, and wherein M+ is a monovalent ion; or a second compound represented by Formula II: R2-C(O)—O−M2+-O—C(O)—R2, wherein R2 is —CH3 or —CH2CH3, and wherein M2+ is a divalent ion. In one embodiment, the buffer solution includes sodium acetate, calcium propionate, and sorbitol.
Claims22
A composition comprising thrombin and collagen in an aqueous buffer solution, wherein the buffer solution includes at least one of a first compound represented by the following Formula I:
- wherein R1 is —CH3, —CH2CH2C(O)OH, or —CH2CH2C(O)O−M+, and wherein M+ is a monovalent ion;
- or
- a second compound represented by the following Formula II:
- wherein R2 is —CH3 or —CH2CH3, and wherein M2+ is a divalent ion.
Dependencies are inferred from the claim text.