Intraoperative and blood derived adhesives
AssigneeThe John Hopkins University
InventorsJennifer H. Elisseeff, Iossif Strehin
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Abstract
The invention features the production of an amine-reactive proteoglycan, specifically chondroitin sulfate or hyaluronic acid. This material can be provided in powder (solid) or liquid form and combined with blood derivatives including serum, platelets, platelet rich plasma, bone marrow, or with other tissue products to form hydrogels. The properties (physical and biological) are different for each of these hydrogels and can be further manipulated by controlling the conditions under which the hydrogels are formed. Such properties include the biodegradability of the hydrogel, the compressibility, the adhesive strength, the presence of pharmaceutical agents or therapeutic cells, and resiliency.
Claims32
An isolated hydrogel composition comprising a blood product and an amine-reacting proteoglycan.
An isolated hydrogel composition produced by incubating an isolated blood product with an amine-reacting proteoglycan.
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A method of filling a void in a subject, said method comprising obtaining a blood product from said subject, incubating said blood product in a mixture with an amine-reacting proteoglycan, wherein said incubation is conducted in, or packed into, a mold shaped to produce an isolated hydrogel that fills said void in said subject.
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An isolated hydrogel composition comprising a tissue product and an amine-reacting proteoglycan.
An isolated hydrogel composition comprising a blood product, an amine-reacting proteoglycan, and a living cell.
Dependencies are inferred from the claim text.