Dinucleotide compounds for hcv infection
OwnerAdel M. MOUSSA, Benjamin Alexander MAYES +2inventors
InventorsAdel M. MOUSSA, Benjamin Alexander MAYES, Jeevanandam ARUMUGASAMY, Jingyang WANG
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Abstract
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds comprise two 2′-methyl nucleotides linked according to Formula I: N1-L-N2 (I) or a pharmaceutically acceptable salt, ester, solvate, stereoisomer, isomeric form, tautomeric form or polymorphic form thereof; wherein N1, L and N2 are as described herein.
Claims24
A compound comprising two 2′-methyl nucleotides linked according to Formula I:
- N1-L-N2 (I)
- or a pharmaceutically acceptable salt, ester, solvate, stereoisomer, tautomeric form or polymorphic form thereof;
- wherein:
- N1 is a 2′-methyl nucleotide;
- N2 is a 2′-methyl nucleotide;
- and
- L is alkylene, cycloalkylene, heteroalkylene, cycloheteroalkylene, arylene or heteroarylene.
(canceled)
Dependencies are inferred from the claim text.