Methods for reducing an adverse immune response to a foreign antigen in a human subject with anti-cd4 antibodies or cd4-binding fragments thereof or cd4-binding molecules

A method of inducing tolerance or reducing an immune response of a human subject to a foreign antigen, the method comprising:

• treating said subject with a regimen, said regimen comprising:
• a) one or more administrations of an anti-CD4 antibody or a CD4-binding fragment thereof or CD4-binding molecule to said subject, the first administration comprising at least 0.05 mg/kg but less than 5 mg/kg of said antibody or the biological equivalent of said fragment;
• and
• b) one or more administrations of said foreign antigen to said subject.

A method of inducing tolerance or reducing an immune response to a foreign antigen in a human subject, said method comprising:

• treating said subject with a regimen, said regimen comprising:
• a) at least one administration of an anti-CD4 antibody or a CD4-binding fragment thereof or CD4-binding molecule;
• and
• b) at least one administration of said foreign antigen,
• wherein the minimum concentration of said antibody or fragment in the blood of said subject is not less than 5 μg/mL during a tolerizing window.