Methods to treat pancreatic inflammation and associated lung injury through regulation of pancreatic interleukin-22 expression
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsAida Habtezion, Jing Xue
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Abstract
Methods for use of a composition comprising agents that increase pancreatic interleukin-22 production in the treatment of pancreatic inflammatory disorders including pancreatitis-associated acute lung injury.
Claims11
A method of attenuating an acute pancreatic inflammation in a mammalian subject, comprising administering a composition comprising a regulator of pancreatic interleukin-22 (IL-22) expression in a dosage and dosing regimen effective to attenuate pancreatic inflammation and pancreatic tissue damage in said mammalian subject.
A method of attenuating a pancreatic inflammation in a mammalian subject at risk of developing a chronic pancreatic disorder, comprising administering a composition comprising a regulator of pancreatic IL-22 expression in a dosage and dosing regimen effective to attenuate pancreatic inflammation and pancreatic tissue damage in said mammalian subject.
A method of attenuating acute lung injury that is associated with pancreatic inflammation in a mammalian subject, comprising administering a composition comprising a regulator of pancreatic IL-22 expression in a dosage and dosing regimen effective to attenuate said acute lung injury that is associated with pancreatic inflammation in said mammalian subject.
Dependencies are inferred from the claim text.