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US 2014/0112870 A1Published application
NMR spectroscopy and MRI methods and systems
AssigneeVanderbilt University
InventorsKevin Waddell, Chong Cai
Life of this patent
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AssigneeVanderbilt University
InventorsKevin Waddell, Chong Cai
Estimating the term…
A method of performing Nuclear Magnetic Resonance (NMR) spectroscopy or Magnetic Resonance Imaging (MRI). The methods may include: a) generating a compound comprising a first nuclear species (I1), a second nuclear species (I2), a third nuclear species (S), a heteronuclear coupling asymmetry (|J1S−J2S|) and a nuclear singlet state spin order localized on I1 and I2; b) transferring the nuclear singlet state spin order into heteronuclear magnetization localized on S by applying a single, non-recursive pulse sequence at a low magnetic field in the strong coupling regime of protons; and c) performing NMR spectroscopy or MRI with the compound comprising heteronuclear magnetization localized on S. The |J1S−J2S| may be non-zero. The pulse sequence may include a plurality of sequential radio frequency pulses separated by independent evolution interval. The pulse sequence may be capable of transferring at least about 75% of the nuclear singlet state spin order into heteronuclear magnetization localized on S at any |J1S−J2S| when the independent evolution intervals are optimized.
A method of performing Nuclear Magnetic Resonance (NMR) spectroscopy or Magnetic Resonance Imaging (MRI), the method comprising:
The method of claim 0, wherein t1, t2, t3 and t4 are selected to maximize transfer of the nuclear singlet state spin order localized on I1 and I2 into longitudinal net magnetization on S.
The method of claim 0, wherein t1 and t2 are selected to maximize transfer of the nuclear singlet state spin order localized on I1 and I2 into a pure state which is coupled to S, and wherein t3 and t4 are selected to maximize transfer of the pure state which is coupled to S into longitudinal net magnetization on S.
The method of claim 0, wherein t1, t2, t3, t4, t5 and t6 are selected to maximize transfer of the nuclear singlet state spin order localized on I1 and I2 into longitudinal net magnetization on S.
The method of claim 0, wherein t1, t2 and t3 are selected to maximize transfer of the nuclear singlet state spin order localized on I1 and I2 into a pure state which is coupled to S, and wherein t4, t5 and t6 are selected to maximize transfer of the pure state which is coupled to S into longitudinal net magnetization on S.
A method of performing Nuclear Magnetic Resonance (NMR) spectroscopy or Magnetic Resonance Imaging (MRI), the method comprising:
The method of claim 0, wherein the compound has a Hamiltonian of H=2π[J12(I1xI2x+I1yI2y+I1zI2z)+J1SI1zSz+J1RI1zRz+J2SI2zSz+J2RI2zRz+JSRSzRz].
The method of claim 0, wherein the pulse sequence comprises the following sequential steps:
The method of claim 0, wherein t1, t2, t3, t4, t5 and t6 are selected to maximize transfer of the nuclear singlet state spin order localized on II and I2 into longitudinal net magnetization on S.
The method of claim 0, wherein t1, t2 and t3 are selected to maximize transfer of the nuclear singlet state spin order localized on I1 and I2 into a pure state which is coupled to S, and wherein t4, t5 and t6 are selected to maximize transfer of the pure state which is coupled to S into longitudinal net magnetization on S.
A method of performing Nuclear Magnetic Resonance (NMR) spectroscopy or Magnetic Resonance Imaging (MRI), the method comprising:
The method of claim 0, wherein determining J-couplings for a compound comprises experimentally determining J-couplings, theoretically calculating J-couplings and combinations thereof.
The method of claim 0, wherein calculating optimal evolution intervals comprises inverting a density matrix expression representing the evolution of spin states of the compound during application of the pulse sequence to the compound, minimizing the difference between a density matrix expression representing the evolution of spin states of the compound during application of the pulse sequence and a desired state which is coupled to S, or a combination thereof.
Dependencies are inferred from the claim text.