Back to results
US 2014/0112868 A1Published application
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases
AssigneeUniversita' Degli Studi Di Bari Aldo Moro
InventorsNicola Antonio Colabufo, Francesco Berardi, Mariangela Cantore, Marialessandra Contino, Marcello Leopoldo, Roberto Perrone
Life of this patent
Estimating the term…
Abstract
The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.
Claims23
A compound having formula I:
- wherein:
- X is oxygen or sulfur;
- R1 and R2 are selected independently of each other from:
- H, OH, OCH3, NH2, NO2 or a halogen atom selected from:
- F, Cl, Br, I or an alkyl group selected from:
- methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl or terbutyl.
3 more elements
8-10. (canceled)
15-17. (canceled)
Dependencies are inferred from the claim text.