Positron emission tomography imaging method
AssigneePurdue Research Foundation
InventorsPhilip S. Low, Sumith A. Kularatne
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Abstract
Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.
Claims4
1-16. (canceled)
A method for diagnosing or monitoring in a patient a disease state mediated by activated monocytes or activated macrophages having accessible binding sites for a vitamin, the method comprising the steps of:
- a. administering to the patient an effective amount of a composition comprising a compound of the formula
- wherein V is a vitamin receptor binding moiety, or an analog or derivative thereof;
- L is an optional bivalent linker;
- n is an integer selected from 1 to about 100;
- and Ar is an aryl group or a heteroaryl group, that includes one or more substituents (Rf)m comprising a radiophore, where m is an integer selected from 1 to about 3;
- and an optional carrier therefor;
- b. allowing sufficient time for the compound to bind to the activated monocytes or the activated macrophages;
- and
- c. diagnosing or monitoring the disease state extra-corporally using positron emission tomography.
A method of diagnosing or monitoring in a patient a cancer wherein the cancer cells uniquely express, preferentially express, or overexpress vitamin receptors, the method comprising the steps of:
- a. administering to the patient an effective amount of a composition comprising a compound of the formula
- wherein V is a vitamin receptor binding moiety, or an analog or derivative thereof;
- L is an optional bivalent linker;
- n is an integer selected from 1 to about 100;
- and Ar is an aryl group or a heteroaryl group, that includes one or more substituents (Rf)m comprising a radiophore, where m is an integer selected from 1 to about 3;
- and an optional carrier therefor;
- b. allowing sufficient time for the compound to bind to the cancer cells;
- and
- c. diagnosing or monitoring the cancer extra-corporally using positron emission tomography.
A method of diagnosing or monitoring in a patient active atherosclerotic plaques associated with blood vessels wherein the plaques comprise activated macrophages having accessible binding sites for a vitamin, the method comprising the steps of:
- a. administering to the patient an effective amount of a composition comprising a compound of the formula
- wherein V is a vitamin receptor binding moiety, or an analog or derivative thereof;
- L is an optional bivalent linker;
- n is an integer selected from 1 to about 100;
- and Ar is an aryl group or a heteroaryl group, that includes one or more substituents (Rf)m comprising a radiophore, where m is an integer selected from 1 to about 3;
- and an optional carrier therefor;
- b. allowing sufficient time for the compound to bind to activated macrophages associated with active plaques;
- and
- c. diagnosing or monitoring the active plaques extra-corporally using positron emission tomography.
Dependencies are inferred from the claim text.